Abstract
Three open-label, non-comparative, multicentre Phase II trials have examined the efficacy and tolerability of ZD0473 as first-and second-line therapy in non-small-cell lung cancer (NSCLC) patients and second-line therapy in small-cell lung cancer (SCLC) patients. Patients with second-line NSCLC or SCLC were evaluated as either platinum-sensitive or -resistant, based upon their time to relapse/progression after platinum-based therapy. First-line NSCLC patients (n = 18) received a total of 60 treatment cycles (median number per patient 2.5) whilst second-line NSCLC (n = 50) and SCLC (n = 48) patients both received a total of 127 treatment cycles (median number per patient 2.0). Grade 3/4 anaemia, neutropenia and thrombocytopenia was observed in: 38.8%, 22.2% and 27.7% of first-line NSCLC patients; 12.0%, 24.0% and 50% of second-line NSCLC patients; and 10.4%, 25.0% and 47.9% of second-line SCLC patients, respectively. The most common grade 3/4 non-haematological toxicities in all three trials were lethargy and dyspnoea. No clinically significant oto-, nephro- or neurotoxicity was observed. The first-line treatment of NSCLC produced an overall response rate (OR) of 6.3%. No OR was seen after second-line treatment of NSCLC, while ORs of 15.4% and 8.3% were seen in the platinum-resistant and -sensitive second-line SCLC patients, respectively.
Original language | English |
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Pages (from-to) | S13-S18 |
Journal | European Journal of Cancer |
Volume | 38 Suppl 8 |
Issue number | SUPPL. 8 |
DOIs | |
State | Published - 2002 |
Keywords
- Adult
- Aged
- Aged, 80 and over
- Antineoplastic Agents/therapeutic use
- Carcinoma, Non-Small-Cell Lung/drug therapy
- Clinical Trials, Phase II as Topic
- Disease-Free Survival
- Drug Resistance, Neoplasm
- Dyspnea/chemically induced
- Female
- Hematologic Diseases/chemically induced
- Humans
- Lung Neoplasms/drug therapy
- Male
- Middle Aged
- Multicenter Studies as Topic
- Organoplatinum Compounds/therapeutic use
- Sleep Stages/drug effects
- Treatment Outcome
- Lung cancer
- Platinum-resistant
- SCLC
- ZD0473
- NSCLC
- Platinum-sensitive