Abstract
Background: We report local recurrence (LR) after breast-conserving surgery and radiation (BCS+RT) for ductal carcinoma in situ (DCIS) to determine outcomes for patients aged ≤40 years compared with older women. Methods: The study included 440 women with DCIS treated from 1978 to 2007. All patients received whole-breast radiotherapy with a boost in 95% of cases. Demographics, characteristics, surgical, and adjuvant treatments were analyzed for an effect on LR. Results: Median age was 56.5 years with 24 patients aged ≤40. Median DCIS size was 0.8 cm. Re-excision was required in 62% of patients, and in 75% of those aged ≤40. Tamoxifen was used in 22%, but only one patient aged ≤40. Median follow-up was 6.8 years. Actuarial LR was 7% (95% confidence interval of 4-11%) at 10 years and 8% (5-14%) at 15 years. There was no difference in LR by age (P=0.76). Conclusions: The long-term risk of LR after BCS+RT for DCIS is low, even in patients ≤40 years. This may be due to patient selection for small size, high utilization of re-excision, and radiation boost. Young age may be a smaller contributor to LR risk in DCIS than previously suggested.
Original language | English |
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Pages (from-to) | 25-31 |
Number of pages | 7 |
Journal | Journal of Surgical Oncology |
Volume | 100 |
Issue number | 1 |
DOIs | |
State | Published - Jul 1 2009 |
Keywords
- Adult
- Age Factors
- Aged
- Aged, 80 and over
- Breast Neoplasms/therapy
- Carcinoma in Situ/therapy
- Carcinoma, Ductal, Breast/therapy
- Combined Modality Therapy
- Female
- Humans
- Mastectomy, Segmental
- Middle Aged
- Neoplasm Recurrence, Local/etiology