TY - JOUR
T1 - Why are hepadnaviruses DNA and not RNA viruses?
AU - Seeger, Christoph
AU - Hu, Jianming
PY - 1997/11
Y1 - 1997/11
N2 - Virion assembly in hepadnaviruses is a two-step process leading to (1) the packaging of viral pregenomic RNA and reverse transcriptase into nucleocapsids and (2) the assembly of nucleocapsids with envelope components, which results in the formation of mature virus particles. Characteristically, both steps are intimately coupled to viral DNA synthesis. While assembly of nucleocapsids is coupled to the protein priming of reverse transcription, virion formation is linked to genome maturation.
AB - Virion assembly in hepadnaviruses is a two-step process leading to (1) the packaging of viral pregenomic RNA and reverse transcriptase into nucleocapsids and (2) the assembly of nucleocapsids with envelope components, which results in the formation of mature virus particles. Characteristically, both steps are intimately coupled to viral DNA synthesis. While assembly of nucleocapsids is coupled to the protein priming of reverse transcription, virion formation is linked to genome maturation.
KW - DNA, Viral/genetics
KW - DNA-Directed RNA Polymerases/metabolism
KW - Hepadnaviridae/genetics
KW - Nucleocapsid/genetics
KW - RNA, Viral/genetics
KW - RNA-Directed DNA Polymerase/metabolism
KW - Transcription, Genetic
UR - http://www.scopus.com/inward/record.url?scp=0030780251&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=purepublist2023&SrcAuth=WosAPI&KeyUT=WOS:A1997YF71100017&DestLinkType=FullRecord&DestApp=WOS
U2 - 10.1016/S0966-842X(97)01141-4
DO - 10.1016/S0966-842X(97)01141-4
M3 - Review article
C2 - 9402701
SN - 0966-842X
VL - 5
SP - 447
EP - 450
JO - Trends in Microbiology
JF - Trends in Microbiology
IS - 11
ER -