VDAC2 enforces a mitochondrial checkpoint to cancer immunity

Katia Cosentino; Joost Verduijn; Lorenzo Galluzzi

doi:10.1038/s41590-025-02171-1

VDAC2 enforces a mitochondrial checkpoint to cancer immunity

Katia Cosentino, Joost Verduijn, Lorenzo Galluzzi

Cancer Signaling and Microenvironment (CSM)

Research output: Contribution to journal › Comment/debate

Abstract

Mitochondrial integrity controls cellular and immunological homeostasis in various pathophysiological settings. Recent findings suggest that VDAC2 antagonizes the ability of IFNγ to drive mitochondrial permeabilization in malignant cells by inhibiting BAK, thus promoting cell survival and immunoevasion.

Original language	English
Pages (from-to)	808-809
Number of pages	2
Journal	Nature Immunology
Volume	26
Issue number	6
DOIs	https://doi.org/10.1038/s41590-025-02171-1
State	Published - Jun 2025

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/s41590-025-02171-1

Cite this

@article{f5d7fe08bafc479b869efa43fd706a08,

title = "VDAC2 enforces a mitochondrial checkpoint to cancer immunity",

abstract = "Mitochondrial integrity controls cellular and immunological homeostasis in various pathophysiological settings. Recent findings suggest that VDAC2 antagonizes the ability of IFNγ to drive mitochondrial permeabilization in malignant cells by inhibiting BAK, thus promoting cell survival and immunoevasion.",

author = "Katia Cosentino and Joost Verduijn and Lorenzo Galluzzi",

note = "Publisher Copyright: {\textcopyright} Springer Nature America, Inc. 2025.",

year = "2025",

month = jun,

doi = "10.1038/s41590-025-02171-1",

language = "English",

volume = "26",

pages = "808--809",

journal = "Nature Immunology",

issn = "1529-2908",

publisher = "Nature Research",

number = "6",

}

TY - JOUR

T1 - VDAC2 enforces a mitochondrial checkpoint to cancer immunity

AU - Cosentino, Katia

AU - Verduijn, Joost

AU - Galluzzi, Lorenzo

N1 - Publisher Copyright: © Springer Nature America, Inc. 2025.

PY - 2025/6

Y1 - 2025/6

N2 - Mitochondrial integrity controls cellular and immunological homeostasis in various pathophysiological settings. Recent findings suggest that VDAC2 antagonizes the ability of IFNγ to drive mitochondrial permeabilization in malignant cells by inhibiting BAK, thus promoting cell survival and immunoevasion.

AB - Mitochondrial integrity controls cellular and immunological homeostasis in various pathophysiological settings. Recent findings suggest that VDAC2 antagonizes the ability of IFNγ to drive mitochondrial permeabilization in malignant cells by inhibiting BAK, thus promoting cell survival and immunoevasion.

UR - http://www.scopus.com/inward/record.url?scp=105005745669&partnerID=8YFLogxK

U2 - 10.1038/s41590-025-02171-1

DO - 10.1038/s41590-025-02171-1

M3 - Comment/debate

C2 - 40389564

AN - SCOPUS:105005745669

SN - 1529-2908

VL - 26

SP - 808

EP - 809

JO - Nature Immunology

JF - Nature Immunology

IS - 6

ER -

VDAC2 enforces a mitochondrial checkpoint to cancer immunity

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this