VDAC2 enforces a mitochondrial checkpoint to cancer immunity

Katia Cosentino, Joost Verduijn, Lorenzo Galluzzi

Research output: Contribution to journalComment/debate

Abstract

Mitochondrial integrity controls cellular and immunological homeostasis in various pathophysiological settings. Recent findings suggest that VDAC2 antagonizes the ability of IFNγ to drive mitochondrial permeabilization in malignant cells by inhibiting BAK, thus promoting cell survival and immunoevasion.

Original languageEnglish
Pages (from-to)808-809
Number of pages2
JournalNature Immunology
Volume26
Issue number6
DOIs
StatePublished - Jun 2025

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