Variant Philadelphia chromosome translocations in two patients with chronic myelogenous leukemia

Joseph R. Testa, Lydia M. Jumamoy, Peter H. Wiernik

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Two patients with chronic myelogenous leukemia and new variant Philadelphia chromosome translocations are reported. In one case, a 41-year-old male, a 10;22 translocation was found in all bone marrow cells examined. Furthermore, the Y chromosome was missing in 90% of the analyzed metaphase cells. In the second patient, a 22-year-old male, all the marrow cells contained a complex rearrangement involving chromosomes No. 2, 9, and 22.

Original languageEnglish
Pages (from-to)79-84
Number of pages6
JournalCancer Genetics and Cytogenetics
Volume7
Issue number1
DOIs
StatePublished - Sep 1982

Keywords

  • Adult
  • Chromosome Deletion
  • Chromosomes, Human, 1-3/ultrastructure
  • Chromosomes, Human, 21-22 and Y/ultrastructure
  • Chromosomes, Human, 6-12 and X/ultrastructure
  • Genetic Variation
  • Humans
  • Leukemia, Myeloid/genetics
  • Male
  • Translocation, Genetic
  • Y Chromosome/ultrastructure

Fingerprint

Dive into the research topics of 'Variant Philadelphia chromosome translocations in two patients with chronic myelogenous leukemia'. Together they form a unique fingerprint.

Cite this