TY - JOUR
T1 - Validation of genome-wide prostate cancer associations in men of african descent
AU - Chang, Bao Li
AU - Spangler, Elaine
AU - Gallagher, Stephen
AU - Haiman, Christopher A.
AU - Henderson, Brian
AU - Isaacs, William
AU - Benford, Marnita L.
AU - Kidd, Lacreis R.
AU - Cooney, Kathleen
AU - Strom, Sara
AU - Ingles, Sue Ann
AU - Stern, Mariana C.
AU - Corral, Roman
AU - Joshi, Amit D.
AU - Xu, Jianfeng
AU - Giri, Veda N.
AU - Rybicki, Benjamin
AU - Neslund-Dudas, Christine
AU - Kibel, Adam S.
AU - Thompson, Ian M.
AU - Leach, Robin J.
AU - Ostrander, Elaine A.
AU - Stanford, Janet L.
AU - Witte, John
AU - Casey, Graham
AU - Eeles, Rosalind
AU - Hsing, Ann W.
AU - Chanock, Stephen
AU - Hu, Jennifer J.
AU - John, Esther M.
AU - Park, Jong
AU - Stefflova, Klara
AU - Zeigler-Johnson, Charnita
AU - Rebbeck, Timothy R.
N1 - ©2011 AACR.
PY - 2011/1
Y1 - 2011/1
N2 - Background: Genome-wide association studies (GWAS) have identified numerous prostate cancer susceptibility alleles, but these loci have been identified primarily in men of European descent. There is limited information about the role of these loci in men of African descent. Methods: We identified 7,788 prostate cancer cases and controls with genotype data for 47 GWAS- identified loci. Results: We identified significant associations for SNP rs10486567 at JAZF1, rs10993994 at MSMB, rs12418451 and rs7931342 at 11q13, and rs5945572 and rs5945619 at NUDT10/11. These associations were in the same direction and of similar magnitude as those reported in men of European descent. Significance was attained at all reported prostate cancer susceptibility regions at chromosome 8q24, including associations reaching genome-wide significance in region 2. Conclusion: We have validated in men of African descent the associations at some, but not all, prostate cancer susceptibility loci originally identified in European descent populations. This may be due to the heterogeneity in genetic etiology or in the pattern of genetic variation across populations.
AB - Background: Genome-wide association studies (GWAS) have identified numerous prostate cancer susceptibility alleles, but these loci have been identified primarily in men of European descent. There is limited information about the role of these loci in men of African descent. Methods: We identified 7,788 prostate cancer cases and controls with genotype data for 47 GWAS- identified loci. Results: We identified significant associations for SNP rs10486567 at JAZF1, rs10993994 at MSMB, rs12418451 and rs7931342 at 11q13, and rs5945572 and rs5945619 at NUDT10/11. These associations were in the same direction and of similar magnitude as those reported in men of European descent. Significance was attained at all reported prostate cancer susceptibility regions at chromosome 8q24, including associations reaching genome-wide significance in region 2. Conclusion: We have validated in men of African descent the associations at some, but not all, prostate cancer susceptibility loci originally identified in European descent populations. This may be due to the heterogeneity in genetic etiology or in the pattern of genetic variation across populations.
KW - Black People/genetics
KW - Case-Control Studies
KW - Genetic Predisposition to Disease
KW - Genome, Human
KW - Genome-Wide Association Study
KW - Genotype
KW - Humans
KW - Male
KW - Polymorphism, Single Nucleotide
KW - Prostatic Neoplasms/epidemiology
KW - Reproducibility of Results
KW - United Kingdom/epidemiology
KW - United States/epidemiology
UR - http://www.scopus.com/inward/record.url?scp=78651419461&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=purepublist2023&SrcAuth=WosAPI&KeyUT=WOS:000285972800003&DestLinkType=FullRecord&DestApp=WOS
U2 - 10.1158/1055-9965.EPI-10-0698
DO - 10.1158/1055-9965.EPI-10-0698
M3 - Article
C2 - 21071540
SN - 1055-9965
VL - 20
SP - 23
EP - 32
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
IS - 1
ER -
