Using epigenetic modifiers to target cancer stem cell immunoevasion

Claudia Galassi; Ilio Vitale; Lorenzo Galluzzi

doi:10.1016/j.ccell.2021.11.003

Using epigenetic modifiers to target cancer stem cell immunoevasion

Claudia Galassi, Ilio Vitale, Lorenzo Galluzzi

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Two recent reports in Nature highlight a novel mechanism of immunoevasion that relies on the SET domain bifurcated histone lysine methyltransferase 1 (SETDB1)-dependent epigenetic suppression of endogenous retroelements in melanoma cells. Because SETDB1 is highly expressed by the stem cell compartment, these findings delineate an innovative strategy for restoring cancer stem cell immunosurveillance.

Original language	English
Pages (from-to)	1573-1575
Number of pages	3
Journal	Cancer Cell
Volume	39
Issue number	12
DOIs	https://doi.org/10.1016/j.ccell.2021.11.003
State	Published - Dec 13 2021
Externally published	Yes

Keywords

endogenous retroviruses
immune checkpoint inhibitors
KDM5B
MAVS
STING1
type I IFN

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ccell.2021.11.003

Cite this

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title = "Using epigenetic modifiers to target cancer stem cell immunoevasion",

abstract = "Two recent reports in Nature highlight a novel mechanism of immunoevasion that relies on the SET domain bifurcated histone lysine methyltransferase 1 (SETDB1)-dependent epigenetic suppression of endogenous retroelements in melanoma cells. Because SETDB1 is highly expressed by the stem cell compartment, these findings delineate an innovative strategy for restoring cancer stem cell immunosurveillance.",

keywords = "endogenous retroviruses, immune checkpoint inhibitors, KDM5B, MAVS, STING1, type I IFN",

author = "Claudia Galassi and Ilio Vitale and Lorenzo Galluzzi",

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year = "2021",

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AU - Galassi, Claudia

AU - Vitale, Ilio

AU - Galluzzi, Lorenzo

PY - 2021/12/13

Y1 - 2021/12/13

N2 - Two recent reports in Nature highlight a novel mechanism of immunoevasion that relies on the SET domain bifurcated histone lysine methyltransferase 1 (SETDB1)-dependent epigenetic suppression of endogenous retroelements in melanoma cells. Because SETDB1 is highly expressed by the stem cell compartment, these findings delineate an innovative strategy for restoring cancer stem cell immunosurveillance.

AB - Two recent reports in Nature highlight a novel mechanism of immunoevasion that relies on the SET domain bifurcated histone lysine methyltransferase 1 (SETDB1)-dependent epigenetic suppression of endogenous retroelements in melanoma cells. Because SETDB1 is highly expressed by the stem cell compartment, these findings delineate an innovative strategy for restoring cancer stem cell immunosurveillance.

KW - endogenous retroviruses

KW - immune checkpoint inhibitors

KW - KDM5B

KW - MAVS

KW - STING1

KW - type I IFN

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M3 - Article

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AN - SCOPUS:85122843504

SN - 1535-6108

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SP - 1573

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JO - Cancer Cell

JF - Cancer Cell

IS - 12

ER -

Using epigenetic modifiers to target cancer stem cell immunoevasion

Abstract

Keywords

UN SDGs

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