US multicenter outcomes of endoscopic ultrasound-guided gallbladder drainage with lumen-apposing metal stents for acute cholecystitis

Yakira David; Gaurav Kakked; Bradley Confer; Ruchit Shah; Harshit Khara; David L. Diehl; Matthew RichardKrafft Krafft; Sardar M. Shah-Khan; John Y. Nasr; Petros Benias; Arvinde Trindad; Thiruvengada Muniraj; Harry Aslanian; Prabhleen Chahal; John Rodriguez; Douglas G. Adler; Jason Dubroff; Rabi De Latour; Demetrios Tzimas; Lauren Khanna; Gregory Haber; Adam J. Goodman; Nicholas Hoerter; Nishi Pandey; Mena Bakhit; Thomas E. Kowalski; David Loren; Austin Chiang; Alexander Schlachterman; Jose Nieto; Ameya Deshmukh; Yervant Ichkhanian; Mouen A. Khashab; Maan El Halabi; Richard S. Kwon; Anoop Prabhu; Ariosto Hernandez-Lara; Andrew Storm; Tyler M. Berzin; John Ponero; Amrita Sethi; Tamas A. Gonda; Vladimir Kushnir; Natalie Cosgrove; Daniel Mullady; Abdullah Al-Shahrani; Lionel D'Souza; Jonathan Buscaglia; Juan Carlos Bucobo; Vineet Rolston; Prashant Kedia; Franklin Kasmin; Satish Nagula; Nikhil A. Kumta; Christopher DiMaio

doi:10.1055/a-2495-5542

US multicenter outcomes of endoscopic ultrasound-guided gallbladder drainage with lumen-apposing metal stents for acute cholecystitis

Yakira David, Gaurav Kakked, Bradley Confer, Ruchit Shah, Harshit Khara, David L. Diehl, Matthew RichardKrafft Krafft, Sardar M. Shah-Khan, John Y. Nasr, Petros Benias, Arvinde Trindad, Thiruvengada Muniraj, Harry Aslanian, Prabhleen Chahal, John Rodriguez, Douglas G. Adler, Jason Dubroff, Rabi De Latour, Demetrios Tzimas, Lauren KhannaGregory Haber, Adam J. Goodman, Nicholas Hoerter, Nishi Pandey, Mena Bakhit, Thomas E. Kowalski, David Loren, Austin Chiang, Alexander Schlachterman, Jose Nieto, Ameya Deshmukh, Yervant Ichkhanian, Mouen A. Khashab, Maan El Halabi, Richard S. Kwon, Anoop Prabhu, Ariosto Hernandez-Lara, Andrew Storm, Tyler M. Berzin, John Ponero, Amrita Sethi, Tamas A. Gonda, Vladimir Kushnir, Natalie Cosgrove, Daniel Mullady, Abdullah Al-Shahrani, Lionel D'Souza, Jonathan Buscaglia, Juan Carlos Bucobo, Vineet Rolston, Prashant Kedia, Franklin Kasmin, Satish Nagula, Nikhil A. Kumta, Christopher DiMaio

Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND AND STUDY AIMS: EUS-guided gallbladder drainage (EUS-GBD) using lumen apposing metal stents (LAMS) has excellent technical and short-term clinical success for acute cholecystitis (AC). The goals of this study were to determine the long-term clinical outcomes and adverse events (AEs) of EUS-GBD with LAMS.

PATIENTS AND METHODS: A multicenter, retrospective study was conducted at 18 US tertiary care institutions. Inclusion criteria: any AC patient with attempted EUS-GBD with LAMS and minimum 30-day post-procedure follow-up. Long-term clinical success was defined as absence of recurrent acute cholecystitis (RAC) > 30 days and long-term AE was defined as occurring > 30 days from the index procedure.

RESULTS: A total of 109 patients were included. Technical success was achieved in 108 of 109 (99.1%) and initial clinical success in 106 of 109 (97.2%). Long-term clinical success was achieved in 98 of 109 (89.9%) over a median follow-up of 140 days (range 30-1188). On multivariable analysis (MVA), acalculous cholecystitis (odds ratio [OR] 15.93, 95% confidence interval [CI] 1.22-208.52, P = 0.04) and the occurrence of a LAMS-specific AE (OR 63.60, 95% CI 5.08-799.29, P <0.01) were associated with RAC. AEs occurred in 38 of 109 patients (34.9%) at any time, and in 10 of 109 (9.17%) > 30 days from the index procedure. Most long-term AEs (7 of 109; 6.42%) were LAMS-specific. No technical or clinical factors were associated with occurrence of AEs. LAMS were removed in 24 of 109 patients (22%). There was no difference in RAC or AEs whether LAMS was removed or not.

CONCLUSIONS: EUS-GBD with LAMS has a high rate of long-term clinical success and modest AE rates in patients with AC and is a reasonable destination therapy for high-risk surgical candidates.

Original language	English
Article number	a24955542
Pages (from-to)	a24955542
Number of pages	10
Journal	Endoscopy International Open
Volume	13
DOIs	https://doi.org/10.1055/a-2495-5542
State	Published - Jan 13 2025

Keywords

Biliary tract
Endoscopic ultrasonography
Intervention EUS
Performance and complications
Quality and logistical aspects

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10.1055/a-2495-5542

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David, Y., Kakked, G., Confer, B., Shah, R., Khara, H., Diehl, D. L., Krafft, M. R., Shah-Khan, S. M., Nasr, J. Y., Benias, P., Trindad, A., Muniraj, T., Aslanian, H., Chahal, P., Rodriguez, J., Adler, D. G., Dubroff, J., De Latour, R., Tzimas, D., ... DiMaio, C. (2025). US multicenter outcomes of endoscopic ultrasound-guided gallbladder drainage with lumen-apposing metal stents for acute cholecystitis. Endoscopy International Open, 13, a24955542. Article a24955542. https://doi.org/10.1055/a-2495-5542

@article{88907bc5b3324555a266dd43d4af154a,

title = "US multicenter outcomes of endoscopic ultrasound-guided gallbladder drainage with lumen-apposing metal stents for acute cholecystitis",

abstract = "BACKGROUND AND STUDY AIMS: EUS-guided gallbladder drainage (EUS-GBD) using lumen apposing metal stents (LAMS) has excellent technical and short-term clinical success for acute cholecystitis (AC). The goals of this study were to determine the long-term clinical outcomes and adverse events (AEs) of EUS-GBD with LAMS.PATIENTS AND METHODS: A multicenter, retrospective study was conducted at 18 US tertiary care institutions. Inclusion criteria: any AC patient with attempted EUS-GBD with LAMS and minimum 30-day post-procedure follow-up. Long-term clinical success was defined as absence of recurrent acute cholecystitis (RAC) > 30 days and long-term AE was defined as occurring > 30 days from the index procedure.RESULTS: A total of 109 patients were included. Technical success was achieved in 108 of 109 (99.1%) and initial clinical success in 106 of 109 (97.2%). Long-term clinical success was achieved in 98 of 109 (89.9%) over a median follow-up of 140 days (range 30-1188). On multivariable analysis (MVA), acalculous cholecystitis (odds ratio [OR] 15.93, 95% confidence interval [CI] 1.22-208.52, P = 0.04) and the occurrence of a LAMS-specific AE (OR 63.60, 95% CI 5.08-799.29, P <0.01) were associated with RAC. AEs occurred in 38 of 109 patients (34.9%) at any time, and in 10 of 109 (9.17%) > 30 days from the index procedure. Most long-term AEs (7 of 109; 6.42%) were LAMS-specific. No technical or clinical factors were associated with occurrence of AEs. LAMS were removed in 24 of 109 patients (22%). There was no difference in RAC or AEs whether LAMS was removed or not. CONCLUSIONS: EUS-GBD with LAMS has a high rate of long-term clinical success and modest AE rates in patients with AC and is a reasonable destination therapy for high-risk surgical candidates.",

keywords = "Biliary tract, Endoscopic ultrasonography, Intervention EUS, Performance and complications, Quality and logistical aspects",

author = "Yakira David and Gaurav Kakked and Bradley Confer and Ruchit Shah and Harshit Khara and Diehl, {David L.} and Krafft, {Matthew RichardKrafft} and Shah-Khan, {Sardar M.} and Nasr, {John Y.} and Petros Benias and Arvinde Trindad and Thiruvengada Muniraj and Harry Aslanian and Prabhleen Chahal and John Rodriguez and Adler, {Douglas G.} and Jason Dubroff and {De Latour}, Rabi and Demetrios Tzimas and Lauren Khanna and Gregory Haber and Goodman, {Adam J.} and Nicholas Hoerter and Nishi Pandey and Mena Bakhit and Kowalski, {Thomas E.} and David Loren and Austin Chiang and Alexander Schlachterman and Jose Nieto and Ameya Deshmukh and Yervant Ichkhanian and Khashab, {Mouen A.} and {El Halabi}, Maan and Kwon, {Richard S.} and Anoop Prabhu and Ariosto Hernandez-Lara and Andrew Storm and Berzin, {Tyler M.} and John Ponero and Amrita Sethi and Gonda, {Tamas A.} and Vladimir Kushnir and Natalie Cosgrove and Daniel Mullady and Abdullah Al-Shahrani and Lionel D'Souza and Jonathan Buscaglia and Bucobo, {Juan Carlos} and Vineet Rolston and Prashant Kedia and Franklin Kasmin and Satish Nagula and Kumta, {Nikhil A.} and Christopher DiMaio",

note = "The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).",

year = "2025",

month = jan,

day = "13",

doi = "10.1055/a-2495-5542",

language = "English",

volume = "13",

pages = "a24955542",

journal = "Endoscopy International Open",

issn = "2364-3722",

}

David, Y, Kakked, G, Confer, B, Shah, R, Khara, H, Diehl, DL, Krafft, MR, Shah-Khan, SM, Nasr, JY, Benias, P, Trindad, A, Muniraj, T, Aslanian, H, Chahal, P, Rodriguez, J, Adler, DG, Dubroff, J, De Latour, R, Tzimas, D, Khanna, L, Haber, G, Goodman, AJ, Hoerter, N, Pandey, N, Bakhit, M, Kowalski, TE, Loren, D, Chiang, A, Schlachterman, A, Nieto, J, Deshmukh, A, Ichkhanian, Y, Khashab, MA, El Halabi, M, Kwon, RS, Prabhu, A, Hernandez-Lara, A, Storm, A, Berzin, TM, Ponero, J, Sethi, A, Gonda, TA, Kushnir, V, Cosgrove, N, Mullady, D, Al-Shahrani, A, D'Souza, L, Buscaglia, J, Bucobo, JC, Rolston, V, Kedia, P, Kasmin, F, Nagula, S, Kumta, NA & DiMaio, C 2025, 'US multicenter outcomes of endoscopic ultrasound-guided gallbladder drainage with lumen-apposing metal stents for acute cholecystitis', Endoscopy International Open, vol. 13, a24955542, pp. a24955542. https://doi.org/10.1055/a-2495-5542

TY - JOUR

T1 - US multicenter outcomes of endoscopic ultrasound-guided gallbladder drainage with lumen-apposing metal stents for acute cholecystitis

AU - David, Yakira

AU - Kakked, Gaurav

AU - Confer, Bradley

AU - Shah, Ruchit

AU - Khara, Harshit

AU - Diehl, David L.

AU - Krafft, Matthew RichardKrafft

AU - Shah-Khan, Sardar M.

AU - Nasr, John Y.

AU - Benias, Petros

AU - Trindad, Arvinde

AU - Muniraj, Thiruvengada

AU - Aslanian, Harry

AU - Chahal, Prabhleen

AU - Rodriguez, John

AU - Adler, Douglas G.

AU - Dubroff, Jason

AU - De Latour, Rabi

AU - Tzimas, Demetrios

AU - Khanna, Lauren

AU - Haber, Gregory

AU - Goodman, Adam J.

AU - Hoerter, Nicholas

AU - Pandey, Nishi

AU - Bakhit, Mena

AU - Kowalski, Thomas E.

AU - Loren, David

AU - Chiang, Austin

AU - Schlachterman, Alexander

AU - Nieto, Jose

AU - Deshmukh, Ameya

AU - Ichkhanian, Yervant

AU - Khashab, Mouen A.

AU - El Halabi, Maan

AU - Kwon, Richard S.

AU - Prabhu, Anoop

AU - Hernandez-Lara, Ariosto

AU - Storm, Andrew

AU - Berzin, Tyler M.

AU - Ponero, John

AU - Sethi, Amrita

AU - Gonda, Tamas A.

AU - Kushnir, Vladimir

AU - Cosgrove, Natalie

AU - Mullady, Daniel

AU - Al-Shahrani, Abdullah

AU - D'Souza, Lionel

AU - Buscaglia, Jonathan

AU - Bucobo, Juan Carlos

AU - Rolston, Vineet

AU - Kedia, Prashant

AU - Kasmin, Franklin

AU - Nagula, Satish

AU - Kumta, Nikhil A.

AU - DiMaio, Christopher

N1 - The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

PY - 2025/1/13

Y1 - 2025/1/13

N2 - BACKGROUND AND STUDY AIMS: EUS-guided gallbladder drainage (EUS-GBD) using lumen apposing metal stents (LAMS) has excellent technical and short-term clinical success for acute cholecystitis (AC). The goals of this study were to determine the long-term clinical outcomes and adverse events (AEs) of EUS-GBD with LAMS.PATIENTS AND METHODS: A multicenter, retrospective study was conducted at 18 US tertiary care institutions. Inclusion criteria: any AC patient with attempted EUS-GBD with LAMS and minimum 30-day post-procedure follow-up. Long-term clinical success was defined as absence of recurrent acute cholecystitis (RAC) > 30 days and long-term AE was defined as occurring > 30 days from the index procedure.RESULTS: A total of 109 patients were included. Technical success was achieved in 108 of 109 (99.1%) and initial clinical success in 106 of 109 (97.2%). Long-term clinical success was achieved in 98 of 109 (89.9%) over a median follow-up of 140 days (range 30-1188). On multivariable analysis (MVA), acalculous cholecystitis (odds ratio [OR] 15.93, 95% confidence interval [CI] 1.22-208.52, P = 0.04) and the occurrence of a LAMS-specific AE (OR 63.60, 95% CI 5.08-799.29, P <0.01) were associated with RAC. AEs occurred in 38 of 109 patients (34.9%) at any time, and in 10 of 109 (9.17%) > 30 days from the index procedure. Most long-term AEs (7 of 109; 6.42%) were LAMS-specific. No technical or clinical factors were associated with occurrence of AEs. LAMS were removed in 24 of 109 patients (22%). There was no difference in RAC or AEs whether LAMS was removed or not. CONCLUSIONS: EUS-GBD with LAMS has a high rate of long-term clinical success and modest AE rates in patients with AC and is a reasonable destination therapy for high-risk surgical candidates.

AB - BACKGROUND AND STUDY AIMS: EUS-guided gallbladder drainage (EUS-GBD) using lumen apposing metal stents (LAMS) has excellent technical and short-term clinical success for acute cholecystitis (AC). The goals of this study were to determine the long-term clinical outcomes and adverse events (AEs) of EUS-GBD with LAMS.PATIENTS AND METHODS: A multicenter, retrospective study was conducted at 18 US tertiary care institutions. Inclusion criteria: any AC patient with attempted EUS-GBD with LAMS and minimum 30-day post-procedure follow-up. Long-term clinical success was defined as absence of recurrent acute cholecystitis (RAC) > 30 days and long-term AE was defined as occurring > 30 days from the index procedure.RESULTS: A total of 109 patients were included. Technical success was achieved in 108 of 109 (99.1%) and initial clinical success in 106 of 109 (97.2%). Long-term clinical success was achieved in 98 of 109 (89.9%) over a median follow-up of 140 days (range 30-1188). On multivariable analysis (MVA), acalculous cholecystitis (odds ratio [OR] 15.93, 95% confidence interval [CI] 1.22-208.52, P = 0.04) and the occurrence of a LAMS-specific AE (OR 63.60, 95% CI 5.08-799.29, P <0.01) were associated with RAC. AEs occurred in 38 of 109 patients (34.9%) at any time, and in 10 of 109 (9.17%) > 30 days from the index procedure. Most long-term AEs (7 of 109; 6.42%) were LAMS-specific. No technical or clinical factors were associated with occurrence of AEs. LAMS were removed in 24 of 109 patients (22%). There was no difference in RAC or AEs whether LAMS was removed or not. CONCLUSIONS: EUS-GBD with LAMS has a high rate of long-term clinical success and modest AE rates in patients with AC and is a reasonable destination therapy for high-risk surgical candidates.

KW - Biliary tract

KW - Endoscopic ultrasonography

KW - Intervention EUS

KW - Performance and complications

KW - Quality and logistical aspects

UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=purepublist2023&SrcAuth=WosAPI&KeyUT=WOS:001397144600015&DestLinkType=FullRecord&DestApp=WOS_CPL

U2 - 10.1055/a-2495-5542

DO - 10.1055/a-2495-5542

M3 - Article

C2 - 39958659

SN - 2364-3722

VL - 13

SP - a24955542

JO - Endoscopy International Open

JF - Endoscopy International Open

M1 - a24955542

ER -

US multicenter outcomes of endoscopic ultrasound-guided gallbladder drainage with lumen-apposing metal stents for acute cholecystitis

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