US cancer centers of excellence strategies for increased inclusion of racial and ethnic minorities in clinical trials

Jeanne M. Regnante, Nicole A. Richie, Lola Fashoyin-Aje, Michelle Vichnin, Marvella Ford, Upal Basu Roy, Kenneth Turner, Laura Lee Hall, Evelyn Gonzalez, Nestor Esnaola, Luther T. Clark, Homer C. Adams, Olatunji B. Alese, Keerthi Gogineni, Lorna McNeill, Daniel Petereit, Ify Sargeant, Julie Dang, Coleman Obasaju, Quita HighsmithSimon Craddock Lee, Spencer C. Hoover, Erin L. Williams, Moon S. Chen

Research output: Contribution to journalArticlepeer-review

61 Scopus citations


PURPOSE Participation of racial and ethnic minority groups (REMGs) in cancer trials is disproportionately low despite a high prevalence of certain cancers in REMG populations. We aimed to identify notable practices used by leading US cancer centers that facilitate REMG participation in cancer trials. METHODS The National Minority Quality Forum and Sustainable Healthy Communities Diverse Cancer Communities Working Group developed criteria by which to identify eligible US cancer centers—REMGs comprise 10% or more of the catchment area; a 10% to 50% yearly accrual rate of REMGs in cancer trials; and the presence of formal community outreach and diversity enrollment programs. Cancer center leaders were interviewed to ascertain notable practices that facilitate REMG accrual in clinical trials. RESULTS Eight cancer centers that met the Communities Working Group criteria were invited to participate in in-depth interviews. Notable strategies for increased REMG accrual to cancer trials were reported across five broad themes: commitment and center leadership, investigator training and mentoring, community engagement, patient engagement, and operational practices. Specific notable practices included increased engagement of health care professionals, the presence of formal processes for obtaining REMG patient/caregiver input on research projects, and engagement of community groups to drive REMG participation. Centers also reported an increase in the allocation of resources to improving health disparities and increased dedication of research staff to REMG engagement. CONCLUSION We have identified notable practices that facilitate increased participation of REMGs in cancer trials. Wide implementation of such strategies across cancer centers is essential to ensure that all populations benefit from advances in an era of increasingly personalized treatment of cancer.

Original languageEnglish
Pages (from-to)E289-E299
JournalJournal of Oncology Practice
Issue number4
StatePublished - Jul 1 2019


  • Cancer Care Facilities/standards
  • Clinical Trials as Topic
  • Ethnicity
  • Female
  • Humans
  • Male
  • Racial Groups
  • United States


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