Untangling the role of polycomb complexes in chemotherapy resistance

Cihangir Duy; Ari Melnick

doi:10.1158/2159-8290.CD-18-1080

Untangling the role of polycomb complexes in chemotherapy resistance

Cihangir Duy, Ari Melnick

Cornell University

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

In this issue, Maganti and colleagues described an epigenetic link between reduced abundance of Polycomb-related protein MTF2 and chemotherapy resistance in refractory acute myeloid leukemia. MTF2 deficiency impaired expression of the PRC2 complex and deposition of H3K27me3 at many genes, including the key target gene MDM2, leading to increased MDM2 expression that in turn depleted p53 and thereby conferred chemoresistance.

Original language	English
Pages (from-to)	1348-1351
Number of pages	4
Journal	Cancer Discovery
Volume	8
Issue number	11
DOIs	https://doi.org/10.1158/2159-8290.CD-18-1080
State	Published - Nov 2018
Externally published	Yes

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10.1158/2159-8290.CD-18-1080

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title = "Untangling the role of polycomb complexes in chemotherapy resistance",

abstract = "In this issue, Maganti and colleagues described an epigenetic link between reduced abundance of Polycomb-related protein MTF2 and chemotherapy resistance in refractory acute myeloid leukemia. MTF2 deficiency impaired expression of the PRC2 complex and deposition of H3K27me3 at many genes, including the key target gene MDM2, leading to increased MDM2 expression that in turn depleted p53 and thereby conferred chemoresistance.",

author = "Cihangir Duy and Ari Melnick",

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Untangling the role of polycomb complexes in chemotherapy resistance

Abstract

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