Unique GGT→GTT mutation at K-ras codon 12 in six human pancreatic cancer cell lines from Chinese patients

Shuanzeng Wei; Tonghua Liu; Hongrui Liu; Jie Gao

Unique GGT→GTT mutation at K-ras codon 12 in six human pancreatic cancer cell lines from Chinese patients

Shuanzeng Wei
, Tonghua Liu
, Hongrui Liu
, Jie Gao

Chinese Academy of Medical Sciences

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Objective. To investigate the K-ras mutation pattern in six pancreatic cancer cell lines from Chinese patients. Methods. All six cell lines were analyzed for mutations in exon 1 of the K-ras gene by polymerase chain reaction (PCR) and direct sequencing. Results. All 6 pancreatic cancer cell lines had GGT → GTT mutations at K-ras codon 12 but no mutations at codon 13. Conclusion. The unique GGT → GTT mutation at codon 12 plays a potential role in the carcinogenesis of pancreatic cancers in Chinese.

Original language	English
Pages (from-to)	1585-1587
Number of pages	3
Journal	Chinese Medical Journal
Volume	116
Issue number	10
State	Published - Oct 2003
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

K-ras
Mutation
Pancreatic cancer

Cite this

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title = "Unique GGT→GTT mutation at K-ras codon 12 in six human pancreatic cancer cell lines from Chinese patients",

abstract = "Objective. To investigate the K-ras mutation pattern in six pancreatic cancer cell lines from Chinese patients. Methods. All six cell lines were analyzed for mutations in exon 1 of the K-ras gene by polymerase chain reaction (PCR) and direct sequencing. Results. All 6 pancreatic cancer cell lines had GGT → GTT mutations at K-ras codon 12 but no mutations at codon 13. Conclusion. The unique GGT → GTT mutation at codon 12 plays a potential role in the carcinogenesis of pancreatic cancers in Chinese.",

keywords = "K-ras, Mutation, Pancreatic cancer",

author = "Shuanzeng Wei and Tonghua Liu and Hongrui Liu and Jie Gao",

year = "2003",

month = oct,

language = "English",

volume = "116",

pages = "1585--1587",

journal = "Chinese Medical Journal",

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number = "10",

}

TY - JOUR

T1 - Unique GGT→GTT mutation at K-ras codon 12 in six human pancreatic cancer cell lines from Chinese patients

AU - Wei, Shuanzeng

AU - Liu, Tonghua

AU - Liu, Hongrui

AU - Gao, Jie

PY - 2003/10

Y1 - 2003/10

N2 - Objective. To investigate the K-ras mutation pattern in six pancreatic cancer cell lines from Chinese patients. Methods. All six cell lines were analyzed for mutations in exon 1 of the K-ras gene by polymerase chain reaction (PCR) and direct sequencing. Results. All 6 pancreatic cancer cell lines had GGT → GTT mutations at K-ras codon 12 but no mutations at codon 13. Conclusion. The unique GGT → GTT mutation at codon 12 plays a potential role in the carcinogenesis of pancreatic cancers in Chinese.

AB - Objective. To investigate the K-ras mutation pattern in six pancreatic cancer cell lines from Chinese patients. Methods. All six cell lines were analyzed for mutations in exon 1 of the K-ras gene by polymerase chain reaction (PCR) and direct sequencing. Results. All 6 pancreatic cancer cell lines had GGT → GTT mutations at K-ras codon 12 but no mutations at codon 13. Conclusion. The unique GGT → GTT mutation at codon 12 plays a potential role in the carcinogenesis of pancreatic cancers in Chinese.

KW - K-ras

KW - Mutation

KW - Pancreatic cancer

UR - https://www.scopus.com/pages/publications/0345328329

M3 - Article

SN - 0366-6999

VL - 116

SP - 1585

EP - 1587

JO - Chinese Medical Journal

JF - Chinese Medical Journal

IS - 10

ER -

Unique GGT→GTT mutation at K-ras codon 12 in six human pancreatic cancer cell lines from Chinese patients

Abstract

UN SDGs

Keywords

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