Type I interferons in anticancer immunity

Laurence Zitvogel; Lorenzo Galluzzi; Oliver Kepp; Mark J. Smyth; Guido Kroemer

doi:10.1038/nri3845

Type I interferons in anticancer immunity

Laurence Zitvogel
, Lorenzo Galluzzi
, Oliver Kepp
, Mark J. Smyth
, Guido Kroemer

Cancer Signaling and Microenvironment (CSM)

Université Paris-Sud
Institut national de la santé et de la recherche médicale
Université Paris-Saclay
Center of Clinical Investigations in Biotherapies of Cancer (CICBT)
Centre de Recherche des Cordeliers
Université Paris Cité
Sorbonne Université
Queensland Institute of Medical Research
University of Queensland
Assistance publique – Hôpitaux de Paris

Research output: Contribution to journal › Review article › peer-review

1134 Scopus citations

Abstract

Type I interferons (IFNs) are known for their key role in antiviral immune responses. In this Review, we discuss accumulating evidence indicating that type I IFNs produced by malignant cells or tumour-infiltrating dendritic cells also control the autocrine or paracrine circuits that underlie cancer immunosurveillance. Many conventional chemotherapeutics, targeted anticancer agents, immunological adjuvants and oncolytic viruses are only fully efficient in the presence of intact type I IFN signalling. Moreover, the intratumoural expression levels of type I IFNs or of IFN-stimulated genes correlate with favourable disease outcome in several cohorts of patients with cancer. Finally, new anticancer immunotherapies are being developed that are based on recombinant type I IFNs, type I IFN-encoding vectors and type I IFN-expressing cells.

Original language	English
Pages (from-to)	405-414
Number of pages	10
Journal	Nature Reviews Immunology
Volume	15
Issue number	7
DOIs	https://doi.org/10.1038/nri3845
State	Published - Jul 26 2015

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10.1038/nri3845

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title = "Type I interferons in anticancer immunity",

abstract = "Type I interferons (IFNs) are known for their key role in antiviral immune responses. In this Review, we discuss accumulating evidence indicating that type I IFNs produced by malignant cells or tumour-infiltrating dendritic cells also control the autocrine or paracrine circuits that underlie cancer immunosurveillance. Many conventional chemotherapeutics, targeted anticancer agents, immunological adjuvants and oncolytic viruses are only fully efficient in the presence of intact type I IFN signalling. Moreover, the intratumoural expression levels of type I IFNs or of IFN-stimulated genes correlate with favourable disease outcome in several cohorts of patients with cancer. Finally, new anticancer immunotherapies are being developed that are based on recombinant type I IFNs, type I IFN-encoding vectors and type I IFN-expressing cells.",

author = "Laurence Zitvogel and Lorenzo Galluzzi and Oliver Kepp and Smyth, \{Mark J.\} and Guido Kroemer",

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T1 - Type I interferons in anticancer immunity

AU - Zitvogel, Laurence

AU - Galluzzi, Lorenzo

AU - Kepp, Oliver

AU - Smyth, Mark J.

AU - Kroemer, Guido

PY - 2015/7/26

Y1 - 2015/7/26

N2 - Type I interferons (IFNs) are known for their key role in antiviral immune responses. In this Review, we discuss accumulating evidence indicating that type I IFNs produced by malignant cells or tumour-infiltrating dendritic cells also control the autocrine or paracrine circuits that underlie cancer immunosurveillance. Many conventional chemotherapeutics, targeted anticancer agents, immunological adjuvants and oncolytic viruses are only fully efficient in the presence of intact type I IFN signalling. Moreover, the intratumoural expression levels of type I IFNs or of IFN-stimulated genes correlate with favourable disease outcome in several cohorts of patients with cancer. Finally, new anticancer immunotherapies are being developed that are based on recombinant type I IFNs, type I IFN-encoding vectors and type I IFN-expressing cells.

AB - Type I interferons (IFNs) are known for their key role in antiviral immune responses. In this Review, we discuss accumulating evidence indicating that type I IFNs produced by malignant cells or tumour-infiltrating dendritic cells also control the autocrine or paracrine circuits that underlie cancer immunosurveillance. Many conventional chemotherapeutics, targeted anticancer agents, immunological adjuvants and oncolytic viruses are only fully efficient in the presence of intact type I IFN signalling. Moreover, the intratumoural expression levels of type I IFNs or of IFN-stimulated genes correlate with favourable disease outcome in several cohorts of patients with cancer. Finally, new anticancer immunotherapies are being developed that are based on recombinant type I IFNs, type I IFN-encoding vectors and type I IFN-expressing cells.

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M3 - Review article

C2 - 26027717

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SN - 1474-1733

VL - 15

SP - 405

EP - 414

JO - Nature Reviews Immunology

JF - Nature Reviews Immunology

IS - 7

ER -

Type I interferons in anticancer immunity

Abstract

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