TY - JOUR
T1 - TRIMming away colon cancer
T2 - TRIM21-mediated ubiquitination as an activator of the Hippo tumor suppressor pathway
AU - Benton, Dorothy
AU - Chernoff, Jonathan
N1 - Publisher Copyright:
© 2023 Elsevier Ltd
PY - 2023/7/20
Y1 - 2023/7/20
N2 - In this issue of Cell Chemical Biology, Liu et al.1 identify TRIM21-mediated ubiquitination of the Hippo pathway kinase MST2, promoting its dimerization and activation. The antidepressant Vilazodone was found to bind to TRIM21, enhancing its activity toward MST2, increasing Hippo activation, and reducing colorectal cancer metastasis.
AB - In this issue of Cell Chemical Biology, Liu et al.1 identify TRIM21-mediated ubiquitination of the Hippo pathway kinase MST2, promoting its dimerization and activation. The antidepressant Vilazodone was found to bind to TRIM21, enhancing its activity toward MST2, increasing Hippo activation, and reducing colorectal cancer metastasis.
KW - Colonic Neoplasms
KW - Hippo Signaling Pathway
KW - Humans
KW - Protein Serine-Threonine Kinases/metabolism
KW - Serine-Threonine Kinase 3
KW - Signal Transduction
KW - Ubiquitination
UR - http://www.scopus.com/inward/record.url?scp=85165491725&partnerID=8YFLogxK
U2 - 10.1016/j.chembiol.2023.06.023
DO - 10.1016/j.chembiol.2023.06.023
M3 - Comment/debate
C2 - 37478825
SN - 2451-9456
VL - 30
SP - 699
EP - 701
JO - Cell Chemical Biology
JF - Cell Chemical Biology
IS - 7
ER -
