TRIMming away colon cancer: TRIM21-mediated ubiquitination as an activator of the Hippo tumor suppressor pathway

Dorothy Benton, Jonathan Chernoff

Research output: Contribution to journalComment/debate

1 Scopus citations

Abstract

In this issue of Cell Chemical Biology, Liu et al.1 identify TRIM21-mediated ubiquitination of the Hippo pathway kinase MST2, promoting its dimerization and activation. The antidepressant Vilazodone was found to bind to TRIM21, enhancing its activity toward MST2, increasing Hippo activation, and reducing colorectal cancer metastasis.

Original languageEnglish
Pages (from-to)699-701
Number of pages3
JournalCell Chemical Biology
Volume30
Issue number7
DOIs
StatePublished - Jul 20 2023

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