Trial Watch: Oncolytic viro-immunotherapy of hematologic and solid tumors

Jonathan G. Pol; Sarah Lévesque; Samuel T. Workenhe; Shashi Gujar; Fabrice Le Boeuf; Derek R. Clements; Jean Eudes Fahrner; Laetitia Fend; John C. Bell; Karen L. Mossman; Jitka Fucikova; Radek Spisek; Laurence Zitvogel; Guido Kroemer; Lorenzo Galluzzi

doi:10.1080/2162402X.2018.1503032

Trial Watch: Oncolytic viro-immunotherapy of hematologic and solid tumors

Jonathan G. Pol, Sarah Lévesque, Samuel T. Workenhe, Shashi Gujar, Fabrice Le Boeuf, Derek R. Clements, Jean Eudes Fahrner, Laetitia Fend, John C. Bell, Karen L. Mossman, Jitka Fucikova, Radek Spisek, Laurence Zitvogel, Guido Kroemer, Lorenzo Galluzzi

Research output: Contribution to journal › Review article › peer-review

69 Scopus citations

Abstract

Oncolytic viruses selectively target and kill cancer cells in an immunogenic fashion, thus supporting the establishment of therapeutically relevant tumor-specific immune responses. In 2015, the US Food and Drug Administration (FDA) approved the oncolytic herpes simplex virus T-VEC for use in advanced melanoma patients. Since then, a plethora of trials has been initiated to assess the safety and efficacy of multiple oncolytic viruses in patients affected with various malignancies. Here, we summarize recent preclinical and clinical progress in the field of oncolytic virotherapy.

Original language	English
Article number	e1503032
Journal	Oncoimmunology
Volume	7
Issue number	12
DOIs	https://doi.org/10.1080/2162402X.2018.1503032
State	Published - Dec 2 2018
Externally published	Yes

Keywords

CAVATAK
DNX-2401
HF10
MV-NIS
Maraba MG1
Pexa-Vec
REOLYSIN
T-VEC

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/2162402X.2018.1503032

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G. Pol, J., Lévesque, S., Workenhe, S. T., Gujar, S., Le Boeuf, F., R. Clements, D., Fahrner, J. E., Fend, L., C. Bell, J., L. Mossman, K., Fucikova, J., Spisek, R., Zitvogel, L., Kroemer, G., & Galluzzi, L. (2018). Trial Watch: Oncolytic viro-immunotherapy of hematologic and solid tumors. Oncoimmunology, 7(12), Article e1503032. https://doi.org/10.1080/2162402X.2018.1503032

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abstract = "Oncolytic viruses selectively target and kill cancer cells in an immunogenic fashion, thus supporting the establishment of therapeutically relevant tumor-specific immune responses. In 2015, the US Food and Drug Administration (FDA) approved the oncolytic herpes simplex virus T-VEC for use in advanced melanoma patients. Since then, a plethora of trials has been initiated to assess the safety and efficacy of multiple oncolytic viruses in patients affected with various malignancies. Here, we summarize recent preclinical and clinical progress in the field of oncolytic virotherapy.",

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doi = "10.1080/2162402X.2018.1503032",

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T2 - Oncolytic viro-immunotherapy of hematologic and solid tumors

AU - G. Pol, Jonathan

AU - Lévesque, Sarah

AU - Workenhe, Samuel T.

AU - Gujar, Shashi

AU - Le Boeuf, Fabrice

AU - R. Clements, Derek

AU - Fahrner, Jean Eudes

AU - Fend, Laetitia

AU - C. Bell, John

AU - L. Mossman, Karen

AU - Fucikova, Jitka

AU - Spisek, Radek

AU - Zitvogel, Laurence

AU - Kroemer, Guido

AU - Galluzzi, Lorenzo

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N2 - Oncolytic viruses selectively target and kill cancer cells in an immunogenic fashion, thus supporting the establishment of therapeutically relevant tumor-specific immune responses. In 2015, the US Food and Drug Administration (FDA) approved the oncolytic herpes simplex virus T-VEC for use in advanced melanoma patients. Since then, a plethora of trials has been initiated to assess the safety and efficacy of multiple oncolytic viruses in patients affected with various malignancies. Here, we summarize recent preclinical and clinical progress in the field of oncolytic virotherapy.

AB - Oncolytic viruses selectively target and kill cancer cells in an immunogenic fashion, thus supporting the establishment of therapeutically relevant tumor-specific immune responses. In 2015, the US Food and Drug Administration (FDA) approved the oncolytic herpes simplex virus T-VEC for use in advanced melanoma patients. Since then, a plethora of trials has been initiated to assess the safety and efficacy of multiple oncolytic viruses in patients affected with various malignancies. Here, we summarize recent preclinical and clinical progress in the field of oncolytic virotherapy.

KW - CAVATAK

KW - DNX-2401

KW - HF10

KW - MV-NIS

KW - Maraba MG1

KW - Pexa-Vec

KW - REOLYSIN

KW - T-VEC

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DO - 10.1080/2162402X.2018.1503032

M3 - Review article

C2 - 30524901

AN - SCOPUS:85058014194

SN - 2162-4011

VL - 7

JO - Oncoimmunology

JF - Oncoimmunology

IS - 12

M1 - e1503032

ER -

Trial Watch: Oncolytic viro-immunotherapy of hematologic and solid tumors

Abstract

Keywords

UN SDGs

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