TREX1 Cuts Down on Cancer Immunogenicity

Takahiro Yamazaki; Lorenzo Galluzzi

doi:10.1016/j.tcb.2017.06.001

TREX1 Cuts Down on Cancer Immunogenicity

Takahiro Yamazaki
, Lorenzo Galluzzi

Cornell University
Université Paris Cité

Research output: Contribution to journal › Short survey › peer-review

21 Scopus citations

Abstract

Demaria and colleagues have recently identified three prime repair exonuclease 1 (TREX1) as a key determinant for the limited immunogenicity of cancer cells responding to single high-dose radiation. TREX1 stands out as a promising target for the development of novel strategies to boost anticancer immune responses driven by radiation therapy (RT).

Original language	English
Pages (from-to)	543-545
Number of pages	3
Journal	Trends in Cell Biology
Volume	27
Issue number	8
DOIs	https://doi.org/10.1016/j.tcb.2017.06.001
State	Published - Aug 2017
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

abscopal effect
cGAS
checkpoint blockers
immunogenic cell death
STING
type I interferon

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10.1016/j.tcb.2017.06.001

Cite this

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title = "TREX1 Cuts Down on Cancer Immunogenicity",

abstract = "Demaria and colleagues have recently identified three prime repair exonuclease 1 (TREX1) as a key determinant for the limited immunogenicity of cancer cells responding to single high-dose radiation. TREX1 stands out as a promising target for the development of novel strategies to boost anticancer immune responses driven by radiation therapy (RT).",

keywords = "abscopal effect, cGAS, checkpoint blockers, immunogenic cell death, STING, type I interferon",

author = "Takahiro Yamazaki and Lorenzo Galluzzi",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Ltd",

year = "2017",

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doi = "10.1016/j.tcb.2017.06.001",

language = "English",

volume = "27",

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T1 - TREX1 Cuts Down on Cancer Immunogenicity

AU - Yamazaki, Takahiro

AU - Galluzzi, Lorenzo

PY - 2017/8

Y1 - 2017/8

N2 - Demaria and colleagues have recently identified three prime repair exonuclease 1 (TREX1) as a key determinant for the limited immunogenicity of cancer cells responding to single high-dose radiation. TREX1 stands out as a promising target for the development of novel strategies to boost anticancer immune responses driven by radiation therapy (RT).

AB - Demaria and colleagues have recently identified three prime repair exonuclease 1 (TREX1) as a key determinant for the limited immunogenicity of cancer cells responding to single high-dose radiation. TREX1 stands out as a promising target for the development of novel strategies to boost anticancer immune responses driven by radiation therapy (RT).

KW - abscopal effect

KW - cGAS

KW - checkpoint blockers

KW - immunogenic cell death

KW - STING

KW - type I interferon

UR - https://www.scopus.com/pages/publications/85020806657

U2 - 10.1016/j.tcb.2017.06.001

DO - 10.1016/j.tcb.2017.06.001

M3 - Short survey

C2 - 28625463

AN - SCOPUS:85020806657

SN - 0962-8924

VL - 27

SP - 543

EP - 545

JO - Trends in Cell Biology

JF - Trends in Cell Biology

IS - 8

ER -

TREX1 Cuts Down on Cancer Immunogenicity

Abstract

UN SDGs

Keywords

Access to Document

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