TREX1 Cuts Down on Cancer Immunogenicity

Takahiro Yamazaki, Lorenzo Galluzzi

Research output: Contribution to journalShort surveypeer-review

17 Scopus citations

Abstract

Demaria and colleagues have recently identified three prime repair exonuclease 1 (TREX1) as a key determinant for the limited immunogenicity of cancer cells responding to single high-dose radiation. TREX1 stands out as a promising target for the development of novel strategies to boost anticancer immune responses driven by radiation therapy (RT).

Original languageEnglish
Pages (from-to)543-545
Number of pages3
JournalTrends in Cell Biology
Volume27
Issue number8
DOIs
StatePublished - Aug 2017
Externally publishedYes

Keywords

  • abscopal effect
  • cGAS
  • checkpoint blockers
  • immunogenic cell death
  • STING
  • type I interferon

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