Abstract
Demaria and colleagues have recently identified three prime repair exonuclease 1 (TREX1) as a key determinant for the limited immunogenicity of cancer cells responding to single high-dose radiation. TREX1 stands out as a promising target for the development of novel strategies to boost anticancer immune responses driven by radiation therapy (RT).
Original language | English |
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Pages (from-to) | 543-545 |
Number of pages | 3 |
Journal | Trends in Cell Biology |
Volume | 27 |
Issue number | 8 |
DOIs | |
State | Published - Aug 2017 |
Externally published | Yes |
Keywords
- abscopal effect
- cGAS
- checkpoint blockers
- immunogenic cell death
- STING
- type I interferon