Transient Autophagy Inhibition Precipitates Oncogenesis: A Red Flag For Pharmacological Autophagy Inhibitors?

Lorenzo Galluzzi; Guido Kroemer

doi:10.1016/j.tcb.2020.02.004

Transient Autophagy Inhibition Precipitates Oncogenesis: A Red Flag For Pharmacological Autophagy Inhibitors?

Lorenzo Galluzzi, Guido Kroemer

Research output: Contribution to journal › Short survey › peer-review

5 Scopus citations

Abstract

Recent findings demonstrate that transient genetic inhibition of autophagy promotes age-associated pathologies in mice. While autophagy restoration effectively counteracts such disorders, it also exacerbates the incidence of various solid and hematological tumors. These data may cast additional shadows on the clinical potential of autophagy inhibition for cancer therapy.

Original language	English
Pages (from-to)	339-340
Number of pages	2
Journal	Trends in Cell Biology
Volume	30
Issue number	5
DOIs	https://doi.org/10.1016/j.tcb.2020.02.004
State	Published - May 2020
Externally published	Yes

Keywords

ATG5
cardiac fibrosis
chemosensitization
immunosurveillance
longevity
neurodegeneration

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tcb.2020.02.004

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@article{596a1c65754b4408a888d3c70b77fb90,

title = "Transient Autophagy Inhibition Precipitates Oncogenesis: A Red Flag For Pharmacological Autophagy Inhibitors?",

abstract = "Recent findings demonstrate that transient genetic inhibition of autophagy promotes age-associated pathologies in mice. While autophagy restoration effectively counteracts such disorders, it also exacerbates the incidence of various solid and hematological tumors. These data may cast additional shadows on the clinical potential of autophagy inhibition for cancer therapy.",

keywords = "ATG5, cardiac fibrosis, chemosensitization, immunosurveillance, longevity, neurodegeneration",

author = "Lorenzo Galluzzi and Guido Kroemer",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",

year = "2020",

month = may,

doi = "10.1016/j.tcb.2020.02.004",

language = "English",

volume = "30",

pages = "339--340",

journal = "Trends in Cell Biology",

issn = "0962-8924",

publisher = "Elsevier Ltd.",

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T1 - Transient Autophagy Inhibition Precipitates Oncogenesis

T2 - A Red Flag For Pharmacological Autophagy Inhibitors?

AU - Galluzzi, Lorenzo

AU - Kroemer, Guido

PY - 2020/5

Y1 - 2020/5

N2 - Recent findings demonstrate that transient genetic inhibition of autophagy promotes age-associated pathologies in mice. While autophagy restoration effectively counteracts such disorders, it also exacerbates the incidence of various solid and hematological tumors. These data may cast additional shadows on the clinical potential of autophagy inhibition for cancer therapy.

AB - Recent findings demonstrate that transient genetic inhibition of autophagy promotes age-associated pathologies in mice. While autophagy restoration effectively counteracts such disorders, it also exacerbates the incidence of various solid and hematological tumors. These data may cast additional shadows on the clinical potential of autophagy inhibition for cancer therapy.

KW - ATG5

KW - cardiac fibrosis

KW - chemosensitization

KW - immunosurveillance

KW - longevity

KW - neurodegeneration

UR - http://www.scopus.com/inward/record.url?scp=85080082269&partnerID=8YFLogxK

U2 - 10.1016/j.tcb.2020.02.004

DO - 10.1016/j.tcb.2020.02.004

M3 - Short survey

C2 - 32302546

AN - SCOPUS:85080082269

SN - 0962-8924

VL - 30

SP - 339

EP - 340

JO - Trends in Cell Biology

JF - Trends in Cell Biology

IS - 5

ER -

Transient Autophagy Inhibition Precipitates Oncogenesis: A Red Flag For Pharmacological Autophagy Inhibitors?

Abstract

Keywords

UN SDGs

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