Abstract
RNA polymerase II (Pol II) transcription through chromatin is accompanied by formation of small intranucleosomal DNA loops. Pol II captured within a small loop drives accumulation of DNA supercoiling, facilitating further transcription. DNA breaks relieve supercoiling and induce Pol II arrest, allowing detection of DNA damage hidden in chromatin structure.
Original language | English |
---|---|
Pages (from-to) | 91-95 |
Number of pages | 5 |
Journal | Transcription |
Volume | 7 |
Issue number | 3 |
DOIs | |
State | Published - May 26 2016 |
Keywords
- Chromatin
- DNA repair
- DNA supercoiling
- Elongation
- Intermediates
- Intranucleosomal DNA loops
- Mechanism
- Nucleosome
- RNA polymerase II
- Single strand dna breaks
- Structure
- Transcription