Transcription-induced DNA supercoiling: New roles of intranucleosomal DNA loops in DNA repair and transcription

N. S. Gerasimova, N. A. Pestov, O. I. Kulaeva, D. J. Clark, V. M. Studitsky

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

RNA polymerase II (Pol II) transcription through chromatin is accompanied by formation of small intranucleosomal DNA loops. Pol II captured within a small loop drives accumulation of DNA supercoiling, facilitating further transcription. DNA breaks relieve supercoiling and induce Pol II arrest, allowing detection of DNA damage hidden in chromatin structure.

Original languageEnglish
Pages (from-to)91-95
Number of pages5
JournalTranscription
Volume7
Issue number3
DOIs
StatePublished - May 26 2016

Keywords

  • Chromatin
  • DNA repair
  • DNA supercoiling
  • Elongation
  • Intermediates
  • Intranucleosomal DNA loops
  • Mechanism
  • Nucleosome
  • RNA polymerase II
  • Single strand dna breaks
  • Structure
  • Transcription

Fingerprint

Dive into the research topics of 'Transcription-induced DNA supercoiling: New roles of intranucleosomal DNA loops in DNA repair and transcription'. Together they form a unique fingerprint.

Cite this