Abstract
Recent findings by Abrahamian et al. (2024) provides new insights into the relationship between Two Pore Channel 2 (TPC2) activity and the development and progression of melanoma. Melanocyte inducing transcription factor (MITF) is a critical regulator of both melanocyte and melanoma behavior. Abrahamian et al. (2024) show that MITF-high melanoma requires BOTH Rab7a and TPC2 for proliferation, invasion and metastasis. They further identify Wnt signaling as the mediator of this phenomenon; Rab7a induces TPC2 activity in lysosomes and melanosomes, which regulates GSK-3β stability, thereby determining whether β-catenin escapes degradation and translocates to the nucleus to transcribe the MITF gene. These observations provide new insights into the relationship between ion channel function, lysosomal/melanosomal activity and control for oncogenesis and disease progression in melanoma.
Original language | English |
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Article number | 102989 |
Pages (from-to) | 102989 |
Journal | Cell Calcium |
Volume | 125 |
Early online date | Nov 26 2024 |
DOIs |
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State | Published - Jan 2025 |
Keywords
- Animals
- Gene Expression Regulation, Neoplastic
- Humans
- Melanoma/metabolism
- Microphthalmia-Associated Transcription Factor/metabolism
- Neoplasm Metastasis
- Transient Receptor Potential Channels/metabolism
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Investigators from Temple University Release New Data on Melanoma (Tpc2 Controls Mitf Expression and Metastasis In Melanoma)
02/13/25
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