Towards quantitative analysis of gene regulation by enhancers

Ekaterina V. Nizovtseva; Stefjord Todolli; Wilma K. Olson; Vasily M. Studitsky

doi:10.2217/epi-2017-0061

Towards quantitative analysis of gene regulation by enhancers

Ekaterina V. Nizovtseva, Stefjord Todolli, Wilma K. Olson, Vasily M. Studitsky

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

Abstract

Enhancers are regulatory DNA sequences that can activate transcription over large distances. Recent studies have revealed the widespread role of distant activation in eukaryotic gene regulation and in the development of various human diseases, including cancer. Here we review recent progress in the field, focusing on new experimental and computational approaches that quantify the role of chromatin structure and dynamics during enhancer-promoter interactions in vitro and in vivo.

Original language	English
Pages (from-to)	1219-1231
Number of pages	13
Journal	Epigenomics
Volume	9
Issue number	9
DOIs	https://doi.org/10.2217/epi-2017-0061
State	Published - Aug 2017

Keywords

Animals
Chromatin/genetics
Enhancer Elements, Genetic
Epigenesis, Genetic
Genomics/methods
Humans

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title = "Towards quantitative analysis of gene regulation by enhancers",

abstract = "Enhancers are regulatory DNA sequences that can activate transcription over large distances. Recent studies have revealed the widespread role of distant activation in eukaryotic gene regulation and in the development of various human diseases, including cancer. Here we review recent progress in the field, focusing on new experimental and computational approaches that quantify the role of chromatin structure and dynamics during enhancer-promoter interactions in vitro and in vivo.",

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author = "Nizovtseva, {Ekaterina V.} and Stefjord Todolli and Olson, {Wilma K.} and Studitsky, {Vasily M.}",

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AU - Nizovtseva, Ekaterina V.

AU - Todolli, Stefjord

AU - Olson, Wilma K.

AU - Studitsky, Vasily M.

PY - 2017/8

Y1 - 2017/8

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AB - Enhancers are regulatory DNA sequences that can activate transcription over large distances. Recent studies have revealed the widespread role of distant activation in eukaryotic gene regulation and in the development of various human diseases, including cancer. Here we review recent progress in the field, focusing on new experimental and computational approaches that quantify the role of chromatin structure and dynamics during enhancer-promoter interactions in vitro and in vivo.

KW - Animals

KW - Chromatin/genetics

KW - Enhancer Elements, Genetic

KW - Epigenesis, Genetic

KW - Genomics/methods

KW - Humans

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EP - 1231

JO - Epigenomics

JF - Epigenomics

IS - 9

ER -

Towards quantitative analysis of gene regulation by enhancers

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Keywords

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