Towards laser driven hadron cancer radiotherapy: A review of progress

Ken W.D. Ledingham; Paul R. Bolton; Naoya Shikazono; C. M.Charlie Ma

doi:10.3390/app4030402

Towards laser driven hadron cancer radiotherapy: A review of progress

Ken W.D. Ledingham
, Paul R. Bolton
, Naoya Shikazono
, C. M.Charlie Ma

Cancer Signaling and Microenvironment (CSM)

University of Strathclyde
Selcuk University
Ludwig Maximilian University of Munich
Japan Atomic Energy Agency

Research output: Contribution to journal › Review article › peer-review

115 Scopus citations

Abstract

It has been known for about sixty years that proton and heavy ion therapy is a very powerful radiation procedure for treating tumors. It has an innate ability to irradiate tumors with greater doses and spatial selectivity compared with electron and photon therapy and, hence, is a tissue sparing procedure. For more than twenty years, powerful lasers have generated high energy beams of protons and heavy ions and it has, therefore, frequently been speculated that lasers could be used as an alternative to radiofrequency (RF) accelerators to produce the particle beams necessary for cancer therapy. The present paper reviews the progress made towards laser driven hadron cancer therapy and what has still to be accomplished to realize its inherent enormous potential.

Original language	English
Pages (from-to)	402-443
Number of pages	42
Journal	Applied Sciences (Switzerland)
Volume	4
Issue number	3
DOIs	https://doi.org/10.3390/app4030402
State	Published - Sep 1 2014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Accelerators
High power lasers
Laser acceleration
Laser assisted classification of healthy and cancerous tissue
Laser desorption ionization
Laser driven radiation therapy
Laser medical application centres
Proton radiotherapy

Access to Document

10.3390/app4030402

Cite this

@article{32b4545bcbdc4b759a93fc8cd5f406cf,

title = "Towards laser driven hadron cancer radiotherapy: A review of progress",

abstract = "It has been known for about sixty years that proton and heavy ion therapy is a very powerful radiation procedure for treating tumors. It has an innate ability to irradiate tumors with greater doses and spatial selectivity compared with electron and photon therapy and, hence, is a tissue sparing procedure. For more than twenty years, powerful lasers have generated high energy beams of protons and heavy ions and it has, therefore, frequently been speculated that lasers could be used as an alternative to radiofrequency (RF) accelerators to produce the particle beams necessary for cancer therapy. The present paper reviews the progress made towards laser driven hadron cancer therapy and what has still to be accomplished to realize its inherent enormous potential.",

keywords = "Accelerators, High power lasers, Laser acceleration, Laser assisted classification of healthy and cancerous tissue, Laser desorption ionization, Laser driven radiation therapy, Laser medical application centres, Proton radiotherapy",

author = "Ledingham, \{Ken W.D.\} and Bolton, \{Paul R.\} and Naoya Shikazono and Ma, \{C. M.Charlie\}",

note = "Publisher Copyright: {\textcopyright} 2014 by the authors.",

year = "2014",

month = sep,

day = "1",

doi = "10.3390/app4030402",

language = "English",

volume = "4",

pages = "402--443",

journal = "Applied Sciences (Switzerland)",

issn = "2076-3417",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "3",

}

TY - JOUR

T1 - Towards laser driven hadron cancer radiotherapy

T2 - A review of progress

AU - Ledingham, Ken W.D.

AU - Bolton, Paul R.

AU - Shikazono, Naoya

AU - Ma, C. M.Charlie

PY - 2014/9/1

Y1 - 2014/9/1

N2 - It has been known for about sixty years that proton and heavy ion therapy is a very powerful radiation procedure for treating tumors. It has an innate ability to irradiate tumors with greater doses and spatial selectivity compared with electron and photon therapy and, hence, is a tissue sparing procedure. For more than twenty years, powerful lasers have generated high energy beams of protons and heavy ions and it has, therefore, frequently been speculated that lasers could be used as an alternative to radiofrequency (RF) accelerators to produce the particle beams necessary for cancer therapy. The present paper reviews the progress made towards laser driven hadron cancer therapy and what has still to be accomplished to realize its inherent enormous potential.

AB - It has been known for about sixty years that proton and heavy ion therapy is a very powerful radiation procedure for treating tumors. It has an innate ability to irradiate tumors with greater doses and spatial selectivity compared with electron and photon therapy and, hence, is a tissue sparing procedure. For more than twenty years, powerful lasers have generated high energy beams of protons and heavy ions and it has, therefore, frequently been speculated that lasers could be used as an alternative to radiofrequency (RF) accelerators to produce the particle beams necessary for cancer therapy. The present paper reviews the progress made towards laser driven hadron cancer therapy and what has still to be accomplished to realize its inherent enormous potential.

KW - Accelerators

KW - High power lasers

KW - Laser acceleration

KW - Laser assisted classification of healthy and cancerous tissue

KW - Laser desorption ionization

KW - Laser driven radiation therapy

KW - Laser medical application centres

KW - Proton radiotherapy

UR - https://www.scopus.com/pages/publications/84973599204

U2 - 10.3390/app4030402

DO - 10.3390/app4030402

M3 - Review article

AN - SCOPUS:84973599204

SN - 2076-3417

VL - 4

SP - 402

EP - 443

JO - Applied Sciences (Switzerland)

JF - Applied Sciences (Switzerland)

IS - 3

ER -

Towards laser driven hadron cancer radiotherapy: A review of progress

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this