TIM-3 and γδ T cells: new players in breast cancer dissemination

Lorenzo Galluzzi; Claudia Galassi; David L. Wiest

doi:10.1038/s44318-025-00550-w

TIM-3 and γδ T cells: new players in breast cancer dissemination

Lorenzo Galluzzi, Claudia Galassi, David L. Wiest

Cornell University

Research output: Contribution to journal › Article › peer-review

Abstract

γδ T cells, a heterogeneous lymphocyte subset operating at the interface between innate and adaptive immunity, mediate ambivalent and context-dependent effects in oncological settings. Recent work by Rozalén et al, (2025) demonstrates that IL-17-secreting γδ T cells favor the outgrowth of TIM-3⁺ triple-negative breast cancer metastases by establishing local immunosuppression.

Original language	English
Pages (from-to)	5236-5238
Number of pages	3
Journal	EMBO Journal
Volume	44
Issue number	19
Early online date	Aug 26 2025
DOIs	https://doi.org/10.1038/s44318-025-00550-w https://doi.org/10.1038/s44318-025-00550-w
State	Published - Oct 2025

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title = "TIM-3 and γδ T cells: new players in breast cancer dissemination",

abstract = "γδ T cells, a heterogeneous lymphocyte subset operating at the interface between innate and adaptive immunity, mediate ambivalent and context-dependent effects in oncological settings. Recent work by Rozal{\'e}n et al, (2025) demonstrates that IL-17-secreting γδ T cells favor the outgrowth of TIM-3+ triple-negative breast cancer metastases by establishing local immunosuppression.",

author = "Lorenzo Galluzzi and Claudia Galassi and Wiest, \{David L.\}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2025.",

year = "2025",

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language = "English",

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T2 - new players in breast cancer dissemination

AU - Galluzzi, Lorenzo

AU - Galassi, Claudia

AU - Wiest, David L.

N1 - Publisher Copyright: © The Author(s) 2025.

PY - 2025/10

Y1 - 2025/10

N2 - γδ T cells, a heterogeneous lymphocyte subset operating at the interface between innate and adaptive immunity, mediate ambivalent and context-dependent effects in oncological settings. Recent work by Rozalén et al, (2025) demonstrates that IL-17-secreting γδ T cells favor the outgrowth of TIM-3+ triple-negative breast cancer metastases by establishing local immunosuppression.

AB - γδ T cells, a heterogeneous lymphocyte subset operating at the interface between innate and adaptive immunity, mediate ambivalent and context-dependent effects in oncological settings. Recent work by Rozalén et al, (2025) demonstrates that IL-17-secreting γδ T cells favor the outgrowth of TIM-3+ triple-negative breast cancer metastases by establishing local immunosuppression.

UR - https://www.scopus.com/pages/publications/105014621499

U2 - 10.1038/s44318-025-00550-w

DO - 10.1038/s44318-025-00550-w

M3 - Article

C2 - 40859036

SN - 0261-4189

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SP - 5236

EP - 5238

JO - EMBO Journal

JF - EMBO Journal

IS - 19

ER -

TIM-3 and γδ T cells: new players in breast cancer dissemination

Abstract

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