Thyroid carcinoma. A clinical and pathologic study of 125 cases

Christopher M. Frauenhoffer, Arthur S. Patchefsky, Adnan Cobanoglu

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

Retrospective clinicopathological study of 125 thyroid carcinoma cases followed for 9 to 19 years was performed. Case selection for unfavorable histologic type and advanced disease was observed for referred cases. All medullary and anaplastic tumors were in patients over age 40; younger patients all had papillary and follicular carcinoma. Actuarial survival rates showed favorable outcome for papillary carcinoma followed by follicular and medullary or anaplastic tumors. Within the papillary carcinoma group, older age and male sex adversely affected survival; the former appeared related to clinical stage at presentation. Clinically palpable papillary carcinomas that were poorly circumscribed or showed vascular invasion were associated with poorer survival than tumors without these features. For papillary carcinomas under 1.5 cm, soft tissue invasion, vascular invasion, and occult lymph node metastases did not effect disease free survival. Two deaths from thyroid cancer were observed in this group, however, in patients who presented initially with distant metastases. The biology of these small lesions is briefly discussed.

Original languageEnglish
Pages (from-to)2414-2421
Number of pages8
JournalCancer
Volume43
Issue number6
DOIs
StatePublished - Jun 1979

Keywords

  • Adenocarcinoma/mortality
  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Carcinoma, Papillary/mortality
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Metastasis
  • Neoplasm Staging
  • Prognosis
  • Sex Factors
  • Thyroid Neoplasms/mortality

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