TY - GEN
T1 - Thermosensitive / photocrosslinkable hydrogel for soft tissue scaffold printing
AU - Geisler, Chris G.
AU - Li, Ho Lung
AU - Zhang, Qingwei
AU - Zhou, Jack G.
AU - Wootton, David M.
AU - Lelkes, Peter I.
PY - 2011
Y1 - 2011
N2 - A new type of hydrogel for solid free-form fabrication (SFF) and rapid prototyping (RP) that obtains the qualities of a photocrosslinkable and thermosensitive hydrogel would benefit the tissue engineering field. For a material to best suit SFF and RP, it must: 1) be a low- viscous solution before being printed, 2) involve easily joined on-substrate mixing to form a homogenous gel, 3) have a short solution to gel transition time, 4) be a mechanically strong gel, and 5) have an irreversible gelation processes. A biodegradable, biocompatable thermosensitive triblock copolymer, poly(ethylene glycol-b-(DLlactic acid-co-glycolic acid)-b-ethylene glycol) (PEG-PLGA-PEG), crosslinked with photocrosslinkable Irgacure 2959 allows for quick irreversible transition from solution to gel with a post-processing step utilizing UV light. A material that gels instantaneously from a non-viscous solution to a 3-dimensional building gel could be used in multiple different types of SFF methods already developed. Since the material is also biocompatible, it can be used to replicate many different types of tissues. In this paper, the mechanism of gelation is proposed and the material relationship to the initial viscosity is investigated.
AB - A new type of hydrogel for solid free-form fabrication (SFF) and rapid prototyping (RP) that obtains the qualities of a photocrosslinkable and thermosensitive hydrogel would benefit the tissue engineering field. For a material to best suit SFF and RP, it must: 1) be a low- viscous solution before being printed, 2) involve easily joined on-substrate mixing to form a homogenous gel, 3) have a short solution to gel transition time, 4) be a mechanically strong gel, and 5) have an irreversible gelation processes. A biodegradable, biocompatable thermosensitive triblock copolymer, poly(ethylene glycol-b-(DLlactic acid-co-glycolic acid)-b-ethylene glycol) (PEG-PLGA-PEG), crosslinked with photocrosslinkable Irgacure 2959 allows for quick irreversible transition from solution to gel with a post-processing step utilizing UV light. A material that gels instantaneously from a non-viscous solution to a 3-dimensional building gel could be used in multiple different types of SFF methods already developed. Since the material is also biocompatible, it can be used to replicate many different types of tissues. In this paper, the mechanism of gelation is proposed and the material relationship to the initial viscosity is investigated.
UR - http://www.scopus.com/inward/record.url?scp=82455166991&partnerID=8YFLogxK
U2 - 10.1115/MSEC2011-50166
DO - 10.1115/MSEC2011-50166
M3 - Conference contribution
AN - SCOPUS:82455166991
SN - 9780791844304
T3 - ASME 2011 International Manufacturing Science and Engineering Conference, MSEC 2011
SP - 49
EP - 54
BT - ASME 2011 International Manufacturing Science and Engineering Conference, MSEC 2011
T2 - ASME 2011 International Manufacturing Science and Engineering Conference, MSEC 2011
Y2 - 13 June 2011 through 17 June 2011
ER -