Therapy and prognosis of BRCA-associated ovarian cancer

Christina S. Chu; Stephen C. Rubin

Therapy and prognosis of BRCA-associated ovarian cancer

University of Pennsylvania

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Only about 10% of cases of epithelial ovarian cancer (EOC) are due to an inherited predisposition (1-5), with a majority of these attributable to alterations in the BRCA1 and BRCA2 genes and a small contribution due to mutations in the DNA mismatch repair genes involved in the Lynch II or hereditary nonpolyposis colorectal carcinoma syndrome. For BRCA mutation carriers, the lifetime risk for ovarian cancer is estimated to be between 20% and 40%.

Original language	English
Title of host publication	Hereditary Gynecologic Cancer
Subtitle of host publication	Risk, Prevention and Management
Publisher	CRC Press
Pages	117-127
Number of pages	11
ISBN (Electronic)	9781420052886
ISBN (Print)	142005287X, 9781420052879
State	Published - Jan 1 2008
Externally published	Yes

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Cite this

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title = "Therapy and prognosis of BRCA-associated ovarian cancer",

abstract = "Only about 10% of cases of epithelial ovarian cancer (EOC) are due to an inherited predisposition (1-5), with a majority of these attributable to alterations in the BRCA1 and BRCA2 genes and a small contribution due to mutations in the DNA mismatch repair genes involved in the Lynch II or hereditary nonpolyposis colorectal carcinoma syndrome. For BRCA mutation carriers, the lifetime risk for ovarian cancer is estimated to be between 20% and 40%.",

author = "Chu, {Christina S.} and Rubin, {Stephen C.}",

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AU - Rubin, Stephen C.

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N2 - Only about 10% of cases of epithelial ovarian cancer (EOC) are due to an inherited predisposition (1-5), with a majority of these attributable to alterations in the BRCA1 and BRCA2 genes and a small contribution due to mutations in the DNA mismatch repair genes involved in the Lynch II or hereditary nonpolyposis colorectal carcinoma syndrome. For BRCA mutation carriers, the lifetime risk for ovarian cancer is estimated to be between 20% and 40%.

AB - Only about 10% of cases of epithelial ovarian cancer (EOC) are due to an inherited predisposition (1-5), with a majority of these attributable to alterations in the BRCA1 and BRCA2 genes and a small contribution due to mutations in the DNA mismatch repair genes involved in the Lynch II or hereditary nonpolyposis colorectal carcinoma syndrome. For BRCA mutation carriers, the lifetime risk for ovarian cancer is estimated to be between 20% and 40%.

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M3 - Chapter

AN - SCOPUS:85057415552

SN - 142005287X

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SP - 117

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BT - Hereditary Gynecologic Cancer

PB - CRC Press

ER -

Therapy and prognosis of BRCA-associated ovarian cancer

Abstract

UN SDGs

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