The Underappreciated Role of the Humoral Immune System and B Cells in Tumorigenesis and Cancer Therapeutics: A Review

Victor E. Chen; Benjamin A. Greenberger; James M. Taylor; Martin J. Edelman; Bo Lu

doi:10.1016/j.ijrobp.2020.03.022

The Underappreciated Role of the Humoral Immune System and B Cells in Tumorigenesis and Cancer Therapeutics: A Review

Victor E. Chen, Benjamin A. Greenberger, James M. Taylor, Martin J. Edelman, Bo Lu

Thomas Jefferson University

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

The advent of immunotherapy has ushered in a new era in both cancer research and cancer treatment strategies. Published reviews have described potential mechanisms for therapeutic synergisms from the combination of radiation therapy and immunotherapy, largely overlooking the role of humoral immunity by only focusing on cellular immunity. Given that these 2 branches of the immune system are highly interdependent, in this review we detail both what has already been established regarding the role of humoral immunity in cancer and propose potential avenues that are ripe for further investigation and potential clinical applications.

Original language	English
Pages (from-to)	38-45
Number of pages	8
Journal	International Journal of Radiation Oncology Biology Physics
Volume	108
Issue number	1
DOIs	https://doi.org/10.1016/j.ijrobp.2020.03.022
State	Published - Sep 1 2020

Keywords

Animals
B-Lymphocytes/immunology
Carcinogenesis/immunology
Humans
Immunity, Humoral
Neoplasms/immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ijrobp.2020.03.022

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abstract = "The advent of immunotherapy has ushered in a new era in both cancer research and cancer treatment strategies. Published reviews have described potential mechanisms for therapeutic synergisms from the combination of radiation therapy and immunotherapy, largely overlooking the role of humoral immunity by only focusing on cellular immunity. Given that these 2 branches of the immune system are highly interdependent, in this review we detail both what has already been established regarding the role of humoral immunity in cancer and propose potential avenues that are ripe for further investigation and potential clinical applications.",

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AU - Edelman, Martin J.

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KW - Neoplasms/immunology

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The Underappreciated Role of the Humoral Immune System and B Cells in Tumorigenesis and Cancer Therapeutics: A Review

Abstract

Keywords

UN SDGs

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