The roles of Orai and Stim in bone health and disease

Lisa J. Robinson; Harry C. Blair; John B. Barnett; Jonathan Soboloff

doi:10.1016/j.ceca.2019.06.001

The roles of Orai and Stim in bone health and disease

Lisa J. Robinson, Harry C. Blair, John B. Barnett, Jonathan Soboloff

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Abstract

Orai and Stim proteins are the mediators of calcium release-activated calcium signaling and are important in the regulation of bone homeostasis and disease. This includes separate regulatory systems controlling mesenchymal stem cell differentiation to form osteoblasts, which make bone, and differentiation and regulation of osteoclasts, which resorb bone. These systems will be described separately, and their integration and relation to other systems, including Orai and Stim in teeth, will be briefly discussed at the end of this review.

Original language	English
Pages (from-to)	51-58
Number of pages	8
Journal	Cell Calcium
Volume	81
DOIs	https://doi.org/10.1016/j.ceca.2019.06.001
State	Published - Jul 2019

Keywords

Bone remodeling
Mineralization
Osteogenesis
Osteoporosis

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10.1016/j.ceca.2019.06.001

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title = "The roles of Orai and Stim in bone health and disease",

abstract = "Orai and Stim proteins are the mediators of calcium release-activated calcium signaling and are important in the regulation of bone homeostasis and disease. This includes separate regulatory systems controlling mesenchymal stem cell differentiation to form osteoblasts, which make bone, and differentiation and regulation of osteoclasts, which resorb bone. These systems will be described separately, and their integration and relation to other systems, including Orai and Stim in teeth, will be briefly discussed at the end of this review.",

keywords = "Bone remodeling, Mineralization, Osteogenesis, Osteoporosis",

author = "Robinson, {Lisa J.} and Blair, {Harry C.} and Barnett, {John B.} and Jonathan Soboloff",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",

year = "2019",

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language = "English",

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AU - Robinson, Lisa J.

AU - Blair, Harry C.

AU - Barnett, John B.

AU - Soboloff, Jonathan

PY - 2019/7

Y1 - 2019/7

N2 - Orai and Stim proteins are the mediators of calcium release-activated calcium signaling and are important in the regulation of bone homeostasis and disease. This includes separate regulatory systems controlling mesenchymal stem cell differentiation to form osteoblasts, which make bone, and differentiation and regulation of osteoclasts, which resorb bone. These systems will be described separately, and their integration and relation to other systems, including Orai and Stim in teeth, will be briefly discussed at the end of this review.

AB - Orai and Stim proteins are the mediators of calcium release-activated calcium signaling and are important in the regulation of bone homeostasis and disease. This includes separate regulatory systems controlling mesenchymal stem cell differentiation to form osteoblasts, which make bone, and differentiation and regulation of osteoclasts, which resorb bone. These systems will be described separately, and their integration and relation to other systems, including Orai and Stim in teeth, will be briefly discussed at the end of this review.

KW - Bone remodeling

KW - Mineralization

KW - Osteogenesis

KW - Osteoporosis

UR - http://www.scopus.com/inward/record.url?scp=85067035667&partnerID=8YFLogxK

U2 - 10.1016/j.ceca.2019.06.001

DO - 10.1016/j.ceca.2019.06.001

M3 - Review article

C2 - 31201955

SN - 0143-4160

VL - 81

SP - 51

EP - 58

JO - Cell Calcium

JF - Cell Calcium

ER -

The roles of Orai and Stim in bone health and disease

Abstract

Keywords

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