The Role of the WGR Domain in the Functions of PARP1 and PARP2

N. V. Maluchenko; A. N. Korovina; A. A. Saulina; V. M. Studitsky; A. V. Feofanov

doi:10.31857/S0026898423050129

The Role of the WGR Domain in the Functions of PARP1 and PARP2

Translated title of the contribution: The Role of the WGR Domain in the Functions of PARP1 and PARP2

N. V. Maluchenko, A. N. Korovina, A. A. Saulina, V. M. Studitsky, A. V. Feofanov

Research output: Contribution to journal › Review article › peer-review

Abstract

The PARP1 and PARP2 proteins are members of the poly(ADP-ribose) polymerase family involved in the regulation of DNA repair and replication, RNA processing, ribosome biogenesis, transcription, cell division, and cell death. PARP1 and PARP2 are promising targets for the development of anticancer drugs and can be used in the treatment of cardiovascular, neurodegenerative, and other disorders. The WGR domain has been shown to play a central role in the functioning of PARP1 and PARP2 proteins. This review considers the mechanisms of functioning of WGR domains in the PARP1 and PARP2 proteins, which have several similar and specialized properties. Understanding these processes is of great interest to fundamental science and can contribute to the development of more effective and selective inhibitors of PARP1 and PARP2.

Translated title of the contribution	The Role of the WGR Domain in the Functions of PARP1 and PARP2
Original language	Russian
Pages (from-to)	782-791
Number of pages	10
Journal	Molekulyarnaya Biologiya
Volume	57
Issue number	5
DOIs	https://doi.org/10.31857/S0026898423050129
State	Published - Sep 1 2023

Keywords

Antineoplastic Agents
DNA Repair
Poly (ADP-Ribose) Polymerase-1/genetics
Poly(ADP-ribose) Polymerases/genetics

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title = "The Role of the WGR Domain in the Functions of PARP1 and PARP2",

abstract = "The PARP1 and PARP2 proteins are members of the poly(ADP-ribose) polymerase family involved in the regulation of DNA repair and replication, RNA processing, ribosome biogenesis, transcription, cell division, and cell death. PARP1 and PARP2 are promising targets for the development of anticancer drugs and can be used in the treatment of cardiovascular, neurodegenerative, and other disorders. The WGR domain has been shown to play a central role in the functioning of PARP1 and PARP2 proteins. This review considers the mechanisms of functioning of WGR domains in the PARP1 and PARP2 proteins, which have several similar and specialized properties. Understanding these processes is of great interest to fundamental science and can contribute to the development of more effective and selective inhibitors of PARP1 and PARP2.",

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author = "Maluchenko, {N. V.} and Korovina, {A. N.} and Saulina, {A. A.} and Studitsky, {V. M.} and Feofanov, {A. V.}",

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AU - Maluchenko, N. V.

AU - Korovina, A. N.

AU - Saulina, A. A.

AU - Studitsky, V. M.

AU - Feofanov, A. V.

PY - 2023/9/1

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N2 - The PARP1 and PARP2 proteins are members of the poly(ADP-ribose) polymerase family involved in the regulation of DNA repair and replication, RNA processing, ribosome biogenesis, transcription, cell division, and cell death. PARP1 and PARP2 are promising targets for the development of anticancer drugs and can be used in the treatment of cardiovascular, neurodegenerative, and other disorders. The WGR domain has been shown to play a central role in the functioning of PARP1 and PARP2 proteins. This review considers the mechanisms of functioning of WGR domains in the PARP1 and PARP2 proteins, which have several similar and specialized properties. Understanding these processes is of great interest to fundamental science and can contribute to the development of more effective and selective inhibitors of PARP1 and PARP2.

AB - The PARP1 and PARP2 proteins are members of the poly(ADP-ribose) polymerase family involved in the regulation of DNA repair and replication, RNA processing, ribosome biogenesis, transcription, cell division, and cell death. PARP1 and PARP2 are promising targets for the development of anticancer drugs and can be used in the treatment of cardiovascular, neurodegenerative, and other disorders. The WGR domain has been shown to play a central role in the functioning of PARP1 and PARP2 proteins. This review considers the mechanisms of functioning of WGR domains in the PARP1 and PARP2 proteins, which have several similar and specialized properties. Understanding these processes is of great interest to fundamental science and can contribute to the development of more effective and selective inhibitors of PARP1 and PARP2.

KW - Antineoplastic Agents

KW - DNA Repair

KW - Poly (ADP-Ribose) Polymerase-1/genetics

KW - Poly(ADP-ribose) Polymerases/genetics

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JO - Molekulyarnaya Biologiya

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The Role of the WGR Domain in the Functions of PARP1 and PARP2

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Keywords

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