The role of focal adhesion kinase in the emigration of cells from confluent cultures

Halina Trembacz; Joanna Miłoszewska; Bozena Szaniawska; Maciej Małecki; Małgorzata Przybyszewska; Tomasz Skorski; Przemysław Janik

The role of focal adhesion kinase in the emigration of cells from confluent cultures

Halina Trembacz, Joanna Miłoszewska, Bozena Szaniawska, Maciej Małecki, Małgorzata Przybyszewska, Tomasz Skorski, Przemysław Janik

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

We studied the effect of the modification of focal adhesion kinase (FAK) on the growth, migration and adhesion of C3H 10T1/2 cells. Cells transfected with plasmid coding for antisense FAK displayed a low level of FAK protein. Interestingly, the transfected cells achieved a higher saturation density at confluence, and displayed reduced adhesion and enhanced emigration from a confluent layer of cells when stimulated with fibronectin. In conclusion, it can be postulated that FAK plays an important role in the mechanism of contact inhibition.

Original language	English
Pages (from-to)	1047-1057
Number of pages	11
Journal	Cellular and Molecular Biology Letters
Volume	7
Issue number	4
State	Published - 2002
Externally published	Yes

Keywords

Adhesion
Contact Inhibition
FAK
Migration

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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abstract = "We studied the effect of the modification of focal adhesion kinase (FAK) on the growth, migration and adhesion of C3H 10T1/2 cells. Cells transfected with plasmid coding for antisense FAK displayed a low level of FAK protein. Interestingly, the transfected cells achieved a higher saturation density at confluence, and displayed reduced adhesion and enhanced emigration from a confluent layer of cells when stimulated with fibronectin. In conclusion, it can be postulated that FAK plays an important role in the mechanism of contact inhibition.",

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T1 - The role of focal adhesion kinase in the emigration of cells from confluent cultures

AU - Trembacz, Halina

AU - Miłoszewska, Joanna

AU - Szaniawska, Bozena

AU - Małecki, Maciej

AU - Przybyszewska, Małgorzata

AU - Skorski, Tomasz

AU - Janik, Przemysław

PY - 2002

Y1 - 2002

N2 - We studied the effect of the modification of focal adhesion kinase (FAK) on the growth, migration and adhesion of C3H 10T1/2 cells. Cells transfected with plasmid coding for antisense FAK displayed a low level of FAK protein. Interestingly, the transfected cells achieved a higher saturation density at confluence, and displayed reduced adhesion and enhanced emigration from a confluent layer of cells when stimulated with fibronectin. In conclusion, it can be postulated that FAK plays an important role in the mechanism of contact inhibition.

AB - We studied the effect of the modification of focal adhesion kinase (FAK) on the growth, migration and adhesion of C3H 10T1/2 cells. Cells transfected with plasmid coding for antisense FAK displayed a low level of FAK protein. Interestingly, the transfected cells achieved a higher saturation density at confluence, and displayed reduced adhesion and enhanced emigration from a confluent layer of cells when stimulated with fibronectin. In conclusion, it can be postulated that FAK plays an important role in the mechanism of contact inhibition.

KW - Adhesion

KW - Contact Inhibition

KW - FAK

KW - Migration

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JF - Cellular and Molecular Biology Letters

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ER -

The role of focal adhesion kinase in the emigration of cells from confluent cultures

Abstract

Keywords

UN SDGs

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