The involvement of non-B DNA structures in gross chromosomal rearrangements

Albino Bacolla; Marzena Wojciechowska; Beata Kosmider; Jacquelynn E. Larson; Robert D. Wells

doi:10.1016/j.dnarep.2006.05.032

The involvement of non-B DNA structures in gross chromosomal rearrangements

Albino Bacolla, Marzena Wojciechowska, Beata Kosmider, Jacquelynn E. Larson, Robert D. Wells

Cancer Prevention and Control (CPC)

Texas A&M University

Research output: Contribution to journal › Review article › peer-review

80 Scopus citations

Abstract

Non-B DNA conformations adopted by certain types of DNA sequences promote genetic instabilities, especially gross rearrangements including translocations. We conclude the following: (a) slipped (hairpin) structures, cruciforms, triplexes, tetraplexes and i-motifs, and left-handed Z-DNA are formed in chromosomes and elicit profound genetic consequences via recombination-repair, (b) repeating sequences, probably in their non-B conformations, cause gross genomic rearrangements (translocations, deletions, insertions, inversions, and duplications), and (c) these rearrangements are the genetic basis for numerous human diseases including polycystic kidney disease, adrenoleukodystrophy, follicular lymphomas, and spermatogenic failure.

Original language	English
Pages (from-to)	1161-1170
Number of pages	10
Journal	DNA Repair
Volume	5
Issue number	9-10
DOIs	https://doi.org/10.1016/j.dnarep.2006.05.032
State	Published - Sep 8 2006

Keywords

Gross deletions
Hereditary diseases
Low copy repeats (LCRs)
Non-B DNA conformations
Triplet and tetranucleotide repeats

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.dnarep.2006.05.032

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title = "The involvement of non-B DNA structures in gross chromosomal rearrangements",

abstract = "Non-B DNA conformations adopted by certain types of DNA sequences promote genetic instabilities, especially gross rearrangements including translocations. We conclude the following: (a) slipped (hairpin) structures, cruciforms, triplexes, tetraplexes and i-motifs, and left-handed Z-DNA are formed in chromosomes and elicit profound genetic consequences via recombination-repair, (b) repeating sequences, probably in their non-B conformations, cause gross genomic rearrangements (translocations, deletions, insertions, inversions, and duplications), and (c) these rearrangements are the genetic basis for numerous human diseases including polycystic kidney disease, adrenoleukodystrophy, follicular lymphomas, and spermatogenic failure.",

keywords = "Gross deletions, Hereditary diseases, Low copy repeats (LCRs), Non-B DNA conformations, Triplet and tetranucleotide repeats",

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T1 - The involvement of non-B DNA structures in gross chromosomal rearrangements

AU - Bacolla, Albino

AU - Wojciechowska, Marzena

AU - Kosmider, Beata

AU - Larson, Jacquelynn E.

AU - Wells, Robert D.

PY - 2006/9/8

Y1 - 2006/9/8

N2 - Non-B DNA conformations adopted by certain types of DNA sequences promote genetic instabilities, especially gross rearrangements including translocations. We conclude the following: (a) slipped (hairpin) structures, cruciforms, triplexes, tetraplexes and i-motifs, and left-handed Z-DNA are formed in chromosomes and elicit profound genetic consequences via recombination-repair, (b) repeating sequences, probably in their non-B conformations, cause gross genomic rearrangements (translocations, deletions, insertions, inversions, and duplications), and (c) these rearrangements are the genetic basis for numerous human diseases including polycystic kidney disease, adrenoleukodystrophy, follicular lymphomas, and spermatogenic failure.

AB - Non-B DNA conformations adopted by certain types of DNA sequences promote genetic instabilities, especially gross rearrangements including translocations. We conclude the following: (a) slipped (hairpin) structures, cruciforms, triplexes, tetraplexes and i-motifs, and left-handed Z-DNA are formed in chromosomes and elicit profound genetic consequences via recombination-repair, (b) repeating sequences, probably in their non-B conformations, cause gross genomic rearrangements (translocations, deletions, insertions, inversions, and duplications), and (c) these rearrangements are the genetic basis for numerous human diseases including polycystic kidney disease, adrenoleukodystrophy, follicular lymphomas, and spermatogenic failure.

KW - Gross deletions

KW - Hereditary diseases

KW - Low copy repeats (LCRs)

KW - Non-B DNA conformations

KW - Triplet and tetranucleotide repeats

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JO - DNA Repair

JF - DNA Repair

IS - 9-10

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The involvement of non-B DNA structures in gross chromosomal rearrangements

Abstract

Keywords

UN SDGs

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