The heterogeneity of store-operated calcium entry in melanoma

Robert Hooper; M. Raza Zaidi; Jonathan Soboloff

doi:10.1007/s11427-016-5087-5

The heterogeneity of store-operated calcium entry in melanoma

Robert Hooper, M. Raza Zaidi, Jonathan Soboloff

Temple University

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

Calcium is a key regulator of many physiological processes that are perturbed in cancer, such as migration, proliferation and apoptosis. The proteins STIM and Orai mediate store-operated calcium entry (SOCE), the main pathway for calcium entry in non-excitable cells. Changes in the expression and function of STIM and Orai have been found in a range of cancer types and thus implicated in disease progression. Here we discuss the role of STIM, Orai and the SOCE pathway in the progression of melanoma and explore how the heterogeneous nature of melanoma may explain the lack of consensus in the field regarding the role of SOCE in the progression of this disease.

Original language	English
Pages (from-to)	764-769
Number of pages	6
Journal	Science China Life Sciences
Volume	59
Issue number	8
DOIs	https://doi.org/10.1007/s11427-016-5087-5
State	Published - Aug 1 2016

Keywords

Orai1
STIM1
melanoma
metastasis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s11427-016-5087-5

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title = "The heterogeneity of store-operated calcium entry in melanoma",

abstract = "Calcium is a key regulator of many physiological processes that are perturbed in cancer, such as migration, proliferation and apoptosis. The proteins STIM and Orai mediate store-operated calcium entry (SOCE), the main pathway for calcium entry in non-excitable cells. Changes in the expression and function of STIM and Orai have been found in a range of cancer types and thus implicated in disease progression. Here we discuss the role of STIM, Orai and the SOCE pathway in the progression of melanoma and explore how the heterogeneous nature of melanoma may explain the lack of consensus in the field regarding the role of SOCE in the progression of this disease.",

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T1 - The heterogeneity of store-operated calcium entry in melanoma

AU - Hooper, Robert

AU - Zaidi, M. Raza

AU - Soboloff, Jonathan

PY - 2016/8/1

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N2 - Calcium is a key regulator of many physiological processes that are perturbed in cancer, such as migration, proliferation and apoptosis. The proteins STIM and Orai mediate store-operated calcium entry (SOCE), the main pathway for calcium entry in non-excitable cells. Changes in the expression and function of STIM and Orai have been found in a range of cancer types and thus implicated in disease progression. Here we discuss the role of STIM, Orai and the SOCE pathway in the progression of melanoma and explore how the heterogeneous nature of melanoma may explain the lack of consensus in the field regarding the role of SOCE in the progression of this disease.

AB - Calcium is a key regulator of many physiological processes that are perturbed in cancer, such as migration, proliferation and apoptosis. The proteins STIM and Orai mediate store-operated calcium entry (SOCE), the main pathway for calcium entry in non-excitable cells. Changes in the expression and function of STIM and Orai have been found in a range of cancer types and thus implicated in disease progression. Here we discuss the role of STIM, Orai and the SOCE pathway in the progression of melanoma and explore how the heterogeneous nature of melanoma may explain the lack of consensus in the field regarding the role of SOCE in the progression of this disease.

KW - Orai1

KW - STIM1

KW - melanoma

KW - metastasis

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U2 - 10.1007/s11427-016-5087-5

DO - 10.1007/s11427-016-5087-5

M3 - Review article

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SP - 764

EP - 769

JO - Science China Life Sciences

JF - Science China Life Sciences

IS - 8

ER -

The heterogeneity of store-operated calcium entry in melanoma

Abstract

Keywords

UN SDGs

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