The helminth-derived peptide, FhHDM-1, reverses the trained phenotype of NOD bone-marrow-derived macrophages and regulates proinflammatory responses

Susel Loli Quinteros; Nathaniel W Snyder; Adam Chatoff; Fiona Ryan; Bronwyn O'Brien; Sheila Donnelly

doi:10.1002/eji.202350643

The helminth-derived peptide, FhHDM-1, reverses the trained phenotype of NOD bone-marrow-derived macrophages and regulates proinflammatory responses

Susel Loli Quinteros
, Nathaniel W Snyder
, Adam Chatoff
, Fiona Ryan
, Bronwyn O'Brien
, Sheila Donnelly

Cancer Signaling and Microenvironment (CSM)

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

We implicate a phenotype of trained immunity in bone-marrow-derived macrophages in the onset and progression of type 1 diabetes in nonobese diabetic mice. Treatment with FhHDM-1 reversed immune training, reducing histone methylation and glycolysis, and decreasing proinflammatory cytokine production to the same level as macrophages from nondiabetic immune-competent BALB/c mice.

Original language	English
Article number	2350643
Pages (from-to)	e2350643
Journal	European Journal of Immunology
Volume	54
Issue number	6
Early online date	Mar 5 2024
DOIs	https://doi.org/10.1002/eji.202350643
State	Published - Jun 2024

Keywords

FhHDM-1
Helminth therapy
Macrophage
Trained immunity
Type 1 diabetes
Diabetes Mellitus, Type 1/immunology
Macrophages/immunology
Histones/metabolism
Inflammation/immunology
Phenotype
Animals
Glycolysis
Mice, Inbred NOD
Mice
Mice, Inbred BALB C
Cytokines/metabolism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/eji.202350643

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title = "The helminth-derived peptide, FhHDM-1, reverses the trained phenotype of NOD bone-marrow-derived macrophages and regulates proinflammatory responses",

abstract = "We implicate a phenotype of trained immunity in bone-marrow-derived macrophages in the onset and progression of type 1 diabetes in nonobese diabetic mice. Treatment with FhHDM-1 reversed immune training, reducing histone methylation and glycolysis, and decreasing proinflammatory cytokine production to the same level as macrophages from nondiabetic immune-competent BALB/c mice.",

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author = "Quinteros, \{Susel Loli\} and Snyder, \{Nathaniel W\} and Adam Chatoff and Fiona Ryan and Bronwyn O'Brien and Sheila Donnelly",

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year = "2024",

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AU - Snyder, Nathaniel W

AU - Chatoff, Adam

AU - Ryan, Fiona

AU - O'Brien, Bronwyn

AU - Donnelly, Sheila

PY - 2024/6

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AB - We implicate a phenotype of trained immunity in bone-marrow-derived macrophages in the onset and progression of type 1 diabetes in nonobese diabetic mice. Treatment with FhHDM-1 reversed immune training, reducing histone methylation and glycolysis, and decreasing proinflammatory cytokine production to the same level as macrophages from nondiabetic immune-competent BALB/c mice.

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KW - Helminth therapy

KW - Macrophage

KW - Trained immunity

KW - Type 1 diabetes

KW - Diabetes Mellitus, Type 1/immunology

KW - Macrophages/immunology

KW - Histones/metabolism

KW - Inflammation/immunology

KW - Phenotype

KW - Animals

KW - Glycolysis

KW - Mice, Inbred NOD

KW - Mice

KW - Mice, Inbred BALB C

KW - Cytokines/metabolism

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DO - 10.1002/eji.202350643

M3 - Article

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SN - 0014-2980

VL - 54

SP - e2350643

JO - European Journal of Immunology

JF - European Journal of Immunology

IS - 6

M1 - 2350643

ER -

The helminth-derived peptide, FhHDM-1, reverses the trained phenotype of NOD bone-marrow-derived macrophages and regulates proinflammatory responses

Abstract

Keywords

UN SDGs

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