Abstract
We implicate a phenotype of trained immunity in bone-marrow-derived macrophages in the onset and progression of type 1 diabetes in nonobese diabetic mice. Treatment with FhHDM-1 reversed immune training, reducing histone methylation and glycolysis, and decreasing proinflammatory cytokine production to the same level as macrophages from nondiabetic immune-competent BALB/c mice.
Original language | English |
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Article number | 2350643 |
Pages (from-to) | e2350643 |
Journal | European Journal of Immunology |
Volume | 54 |
Issue number | 6 |
Early online date | Mar 5 2024 |
DOIs | |
State | Published - Jun 2024 |
Keywords
- FhHDM-1
- Helminth therapy
- Macrophage
- Trained immunity
- Type 1 diabetes
- Diabetes Mellitus, Type 1/immunology
- Macrophages/immunology
- Histones/metabolism
- Inflammation/immunology
- Phenotype
- Animals
- Glycolysis
- Mice, Inbred NOD
- Mice
- Mice, Inbred BALB C
- Cytokines/metabolism