The helminth-derived peptide, FhHDM-1, reverses the trained phenotype of NOD bone-marrow-derived macrophages and regulates proinflammatory responses

Susel Loli Quinteros, Nathaniel W Snyder, Adam Chatoff, Fiona Ryan, Bronwyn O'Brien, Sheila Donnelly

Research output: Contribution to journalArticlepeer-review

Abstract

We implicate a phenotype of trained immunity in bone-marrow-derived macrophages in the onset and progression of type 1 diabetes in nonobese diabetic mice. Treatment with FhHDM-1 reversed immune training, reducing histone methylation and glycolysis, and decreasing proinflammatory cytokine production to the same level as macrophages from nondiabetic immune-competent BALB/c mice.

Original languageEnglish
Article number2350643
Pages (from-to)e2350643
JournalEuropean Journal of Immunology
Volume54
Issue number6
Early online dateMar 5 2024
DOIs
StatePublished - Jun 2024

Keywords

  • FhHDM-1
  • Helminth therapy
  • Macrophage
  • Trained immunity
  • Type 1 diabetes
  • Diabetes Mellitus, Type 1/immunology
  • Macrophages/immunology
  • Histones/metabolism
  • Inflammation/immunology
  • Phenotype
  • Animals
  • Glycolysis
  • Mice, Inbred NOD
  • Mice
  • Mice, Inbred BALB C
  • Cytokines/metabolism

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