The evolutionary history of effectors downstream of Cdc42 and Rac

Sophie Cotteret, Jonathan Chernoff

Research output: Contribution to journalReview articlepeer-review

68 Scopus citations

Abstract

Cdc42 and Rac - ancient, highly conserved, small GTPases - mediate extracellular signals, triggering changes in transcription and in the actin cytoskeleton. Although dozens of proteins act downstream of these GTPases, a comparison of effector proteins from evolutionarily diverse organisms suggests that six groups of proteins serve as the core machinery for signaling from Cdc42 and Rac.

Original languageEnglish
Article number0002
Pages (from-to)0002.1-0002.8
JournalGenome Biology
Volume3
Issue number2
StatePublished - 2002

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