The autophagic network and cancer

Marissa D. Rybstein; José Manuel Bravo-San Pedro; Guido Kroemer; Lorenzo Galluzzi

doi:10.1038/s41556-018-0042-2

The autophagic network and cancer

Marissa D. Rybstein
, José Manuel Bravo-San Pedro
, Guido Kroemer
, Lorenzo Galluzzi

Cornell University
Université Paris Cité
Sorbonne Université
Centre de Recherche des Cordeliers
Institut national de la santé et de la recherche médicale
Université Paris-Sud
Assistance publique – Hôpitaux de Paris
Karolinska Institutet

Research output: Contribution to journal › Review article › peer-review

266 Scopus citations

Abstract

Mammalian cells harness autophagy to eliminate physiological byproducts of metabolism and cope with microenvironmental perturbations. Moreover, autophagy connects cellular adaptation with extracellular circuitries that impinge on immunity and metabolism. As it links transformed and non-transformed components of the tumour microenvironment, such an autophagic network is important for cancer initiation, progression and response to therapy. Here, we discuss the mechanisms whereby the autophagic network interfaces with multiple aspects of malignant disease.

Original language	English
Pages (from-to)	243-251
Number of pages	9
Journal	Nature Cell Biology
Volume	20
Issue number	3
DOIs	https://doi.org/10.1038/s41556-018-0042-2
State	Published - Mar 1 2018
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1038/s41556-018-0042-2

Cite this

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abstract = "Mammalian cells harness autophagy to eliminate physiological byproducts of metabolism and cope with microenvironmental perturbations. Moreover, autophagy connects cellular adaptation with extracellular circuitries that impinge on immunity and metabolism. As it links transformed and non-transformed components of the tumour microenvironment, such an autophagic network is important for cancer initiation, progression and response to therapy. Here, we discuss the mechanisms whereby the autophagic network interfaces with multiple aspects of malignant disease.",

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AB - Mammalian cells harness autophagy to eliminate physiological byproducts of metabolism and cope with microenvironmental perturbations. Moreover, autophagy connects cellular adaptation with extracellular circuitries that impinge on immunity and metabolism. As it links transformed and non-transformed components of the tumour microenvironment, such an autophagic network is important for cancer initiation, progression and response to therapy. Here, we discuss the mechanisms whereby the autophagic network interfaces with multiple aspects of malignant disease.

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The autophagic network and cancer

Abstract

UN SDGs

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