The AKT1 proto-oncogene maps to human chromosome 14, band q32

Stehen P. Staal; Kay Huebner; Carlo M. Croce; Nasser Z. Parsa; Joseph R. Testa

doi:10.1016/0888-7543(88)90114-0

The AKT1 proto-oncogene maps to human chromosome 14, band q32

Stehen P. Staal
, Kay Huebner
, Carlo M. Croce
, Nasser Z. Parsa
, Joseph R. Testa

Cancer Prevention and Control (CPC)

Johns Hopkins University
Wistar Institute
University of Maryland Cancer Center

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

The human AKT1 gene is the proto-oncogene of the viral oncogene v-akt. The AKT1 gene has been localized to human chromosome 14, band q32, proximal to the heavy-chain immunoglobulin locus (IGHM), by analysis of human-hamster somatic cell hybrids and by in situ hybridization. Chromosome rearrangements of this band which occur in T-lymphoid malignancies and Hodgkin's disease may affect the AKT1 gene.

Original language	English
Pages (from-to)	96-98
Number of pages	3
Journal	Genomics
Volume	2
Issue number	1
DOIs	https://doi.org/10.1016/0888-7543(88)90114-0
State	Published - Jan 1988

Keywords

Animals
Chromosome Mapping
Chromosomes, Human, Pair 14
Humans
Hybrid Cells/cytology
Karyotyping
Proto-Oncogene Mas
Proto-Oncogenes
Retroviridae/genetics

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10.1016/0888-7543(88)90114-0

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abstract = "The human AKT1 gene is the proto-oncogene of the viral oncogene v-akt. The AKT1 gene has been localized to human chromosome 14, band q32, proximal to the heavy-chain immunoglobulin locus (IGHM), by analysis of human-hamster somatic cell hybrids and by in situ hybridization. Chromosome rearrangements of this band which occur in T-lymphoid malignancies and Hodgkin's disease may affect the AKT1 gene.",

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AU - Croce, Carlo M.

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AU - Testa, Joseph R.

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AB - The human AKT1 gene is the proto-oncogene of the viral oncogene v-akt. The AKT1 gene has been localized to human chromosome 14, band q32, proximal to the heavy-chain immunoglobulin locus (IGHM), by analysis of human-hamster somatic cell hybrids and by in situ hybridization. Chromosome rearrangements of this band which occur in T-lymphoid malignancies and Hodgkin's disease may affect the AKT1 gene.

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KW - Hybrid Cells/cytology

KW - Karyotyping

KW - Proto-Oncogene Mas

KW - Proto-Oncogenes

KW - Retroviridae/genetics

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The AKT1 proto-oncogene maps to human chromosome 14, band q32

Abstract

Keywords

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