TGFβR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment

Reza Nejati; Mariusz A. Wasik

doi:10.1016/j.celrep.2020.108221

TGFβR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment

Reza Nejati, Mariusz A. Wasik

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Le et al. show that the TGF-β1-TGFβR kinase-SMAD3 pathway protects leukemia cells from PARP inhibitor (PARPi)-mediated synthetic lethality in the bone marrow microenvironment. The targeting of the TGF-β1 axis restored the sensitivity of leukemia cells to PARPi and prolonged survival of leukemia-bearing mice.

Original language	English
Article number	108221
Journal	Cell Reports
Volume	33
Issue number	1
DOIs	https://doi.org/10.1016/j.celrep.2020.108221
State	Published - Oct 6 2020

Keywords

PARP inhibitor resistance
TGFβR signaling
bone marrow microenvironment

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10.1016/j.celrep.2020.108221

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title = "TGFβR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment",

abstract = "Le et al. show that the TGF-β1-TGFβR kinase-SMAD3 pathway protects leukemia cells from PARP inhibitor (PARPi)-mediated synthetic lethality in the bone marrow microenvironment. The targeting of the TGF-β1 axis restored the sensitivity of leukemia cells to PARPi and prolonged survival of leukemia-bearing mice.",

keywords = "PARP inhibitor resistance, TGFβR signaling, bone marrow microenvironment",

author = "Reza Nejati and Wasik, {Mariusz A.}",

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AU - Wasik, Mariusz A.

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N2 - Le et al. show that the TGF-β1-TGFβR kinase-SMAD3 pathway protects leukemia cells from PARP inhibitor (PARPi)-mediated synthetic lethality in the bone marrow microenvironment. The targeting of the TGF-β1 axis restored the sensitivity of leukemia cells to PARPi and prolonged survival of leukemia-bearing mice.

AB - Le et al. show that the TGF-β1-TGFβR kinase-SMAD3 pathway protects leukemia cells from PARP inhibitor (PARPi)-mediated synthetic lethality in the bone marrow microenvironment. The targeting of the TGF-β1 axis restored the sensitivity of leukemia cells to PARPi and prolonged survival of leukemia-bearing mice.

KW - PARP inhibitor resistance

KW - TGFβR signaling

KW - bone marrow microenvironment

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TGFβR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment

Abstract

Keywords

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Drug Resistance Mechanism in Leukemia Discovered

Histopathology Facility

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TGFβR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment

Abstract

Keywords

Access to Document

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Press/Media

Drug Resistance Mechanism in Leukemia Discovered

Equipment

Histopathology Facility

Cite this