Targeting the IL-1 family members in skin inflammation

Research output: Contribution to journalReview articlepeer-review

73 Scopus citations

Abstract

The IL-1 family of cytokines comprises 11 proteins with pro- and anti-inflammatory functions that are mediated through an equally large group of receptors and coreceptors. Dysregulation of the IL-1 system may lead to diseases such as psoriasis, atopic dermatitis, contact dermatitis and cutaneous lupus erythematosus. These inflammatory skin conditions greatly affect quality of life and life expectancy, and their frequencies are increasing. However, treatment options for these diseases are unsatisfactory. This review briefly summarizes new findings, reported in the past 2 years, implicating IL-1 family members in skin inflammation. Furthermore, how the biological activities of the IL-1 family members may be inhibited is discussed.

Original languageEnglish
Pages (from-to)1211-1220
Number of pages10
JournalCurrent Opinion in Investigational Drugs
Volume11
Issue number11
StatePublished - Nov 2010
Externally publishedYes

Keywords

  • Anti-inflammatory
  • IL-1
  • IL-1 family
  • IL-33
  • cytokine
  • inflammation
  • skin

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