Targeting Mutant KRAS for Immunogenic Cell Death Induction

Lorenzo Galluzzi

doi:10.1016/j.tips.2019.11.004

Targeting Mutant KRAS for Immunogenic Cell Death Induction

Lorenzo Galluzzi

Cornell University
Yale University
Université Paris Cité

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Although somatic KRAS mutations are common in human tumors, no inhibitor of mutant KRAS was clinically available until recently. Canon and colleagues describe the ability of a clinically available KRAS^G12C inhibitor to drive immunogenic cancer cell death, thus constituting a promising combinatorial partner for immune checkpoint blockers.

Original language	English
Pages (from-to)	1-3
Number of pages	3
Journal	Trends in Pharmacological Sciences
Volume	41
Issue number	1
DOIs	https://doi.org/10.1016/j.tips.2019.11.004
State	Published - Jan 2020
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Antineoplastic Agents/therapeutic use
Humans
Immunogenic Cell Death
Lung Neoplasms/drug therapy
Mutation
Proto-Oncogene Proteins p21(ras)/genetics

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10.1016/j.tips.2019.11.004

Cite this

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title = "Targeting Mutant KRAS for Immunogenic Cell Death Induction",

abstract = "Although somatic KRAS mutations are common in human tumors, no inhibitor of mutant KRAS was clinically available until recently. Canon and colleagues describe the ability of a clinically available KRASG12C inhibitor to drive immunogenic cancer cell death, thus constituting a promising combinatorial partner for immune checkpoint blockers.",

keywords = "Antineoplastic Agents/therapeutic use, Humans, Immunogenic Cell Death, Lung Neoplasms/drug therapy, Mutation, Proto-Oncogene Proteins p21(ras)/genetics",

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year = "2020",

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AB - Although somatic KRAS mutations are common in human tumors, no inhibitor of mutant KRAS was clinically available until recently. Canon and colleagues describe the ability of a clinically available KRASG12C inhibitor to drive immunogenic cancer cell death, thus constituting a promising combinatorial partner for immune checkpoint blockers.

KW - Antineoplastic Agents/therapeutic use

KW - Humans

KW - Immunogenic Cell Death

KW - Lung Neoplasms/drug therapy

KW - Mutation

KW - Proto-Oncogene Proteins p21(ras)/genetics

UR - https://www.scopus.com/pages/publications/85076245723

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DO - 10.1016/j.tips.2019.11.004

M3 - Article

C2 - 31818506

AN - SCOPUS:85076245723

SN - 0165-6147

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EP - 3

JO - Trends in Pharmacological Sciences

JF - Trends in Pharmacological Sciences

IS - 1

ER -

Targeting Mutant KRAS for Immunogenic Cell Death Induction

Abstract

UN SDGs

Keywords

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