TY - JOUR
T1 - Targeting mitochondria for cardiovascular disorders
T2 - therapeutic potential and obstacles
AU - Bonora, Massimo
AU - Wieckowski, Mariusz R.
AU - Sinclair, David A.
AU - Kroemer, Guido
AU - Pinton, Paolo
AU - Galluzzi, Lorenzo
N1 - Publisher Copyright:
© 2018, Springer Nature Limited.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - A large body of evidence indicates that mitochondrial dysfunction has a major role in the pathogenesis of multiple cardiovascular disorders. Over the past 2 decades, extraordinary efforts have been focused on the development of agents that specifically target mitochondria for the treatment of cardiovascular disease. Despite such an intensive wave of investigation, no drugs specifically conceived to modulate mitochondrial functions are currently available for the clinical management of cardiovascular disease. In this Review, we discuss the therapeutic potential of targeting mitochondria in patients with cardiovascular disease, examine the obstacles that have restrained the development of mitochondria-targeting agents thus far, and identify strategies that might empower the full clinical potential of this approach.
AB - A large body of evidence indicates that mitochondrial dysfunction has a major role in the pathogenesis of multiple cardiovascular disorders. Over the past 2 decades, extraordinary efforts have been focused on the development of agents that specifically target mitochondria for the treatment of cardiovascular disease. Despite such an intensive wave of investigation, no drugs specifically conceived to modulate mitochondrial functions are currently available for the clinical management of cardiovascular disease. In this Review, we discuss the therapeutic potential of targeting mitochondria in patients with cardiovascular disease, examine the obstacles that have restrained the development of mitochondria-targeting agents thus far, and identify strategies that might empower the full clinical potential of this approach.
UR - http://www.scopus.com/inward/record.url?scp=85053041945&partnerID=8YFLogxK
U2 - 10.1038/s41569-018-0074-0
DO - 10.1038/s41569-018-0074-0
M3 - Review article
C2 - 30177752
AN - SCOPUS:85053041945
SN - 1759-5002
VL - 16
SP - 33
EP - 55
JO - Nature Reviews Cardiology
JF - Nature Reviews Cardiology
IS - 1
ER -
