Targeting HSP70 for Cancer Therapy

Lorenzo Galluzzi; Fabrizio Giordanetto; Guido Kroemer

doi:10.1016/j.molcel.2009.10.003

Targeting HSP70 for Cancer Therapy

Lorenzo Galluzzi
, Fabrizio Giordanetto
, Guido Kroemer

Cancer Signaling and Microenvironment (CSM)

Research output: Contribution to journal › Short survey › peer-review

45 Scopus citations

Abstract

In a recent issue of Molecular Cell, Leu et al. (2009) demonstrate that a chemical inhibitor of HSP70 exerts prominent tumor-selective cytotoxic effects, thereby lending further support to the notion that non-oncogene addiction constitutes a promising target for anticancer therapy.

Original language	English
Pages (from-to)	176-177
Number of pages	2
Journal	Molecular Cell
Volume	36
Issue number	2
DOIs	https://doi.org/10.1016/j.molcel.2009.10.003
State	Published - Oct 23 2009

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Animals
Drug Resistance, Neoplasm/drug effects
HSP70 Heat-Shock Proteins/metabolism
HSP90 Heat-Shock Proteins/metabolism
Humans
Models, Molecular
Neoplasms/therapy
Sulfonamides/pharmacology

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10.1016/j.molcel.2009.10.003

Cite this

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title = "Targeting HSP70 for Cancer Therapy",

abstract = "In a recent issue of Molecular Cell, Leu et al. (2009) demonstrate that a chemical inhibitor of HSP70 exerts prominent tumor-selective cytotoxic effects, thereby lending further support to the notion that non-oncogene addiction constitutes a promising target for anticancer therapy.",

keywords = "Animals, Drug Resistance, Neoplasm/drug effects, HSP70 Heat-Shock Proteins/metabolism, HSP90 Heat-Shock Proteins/metabolism, Humans, Models, Molecular, Neoplasms/therapy, Sulfonamides/pharmacology",

author = "Lorenzo Galluzzi and Fabrizio Giordanetto and Guido Kroemer",

year = "2009",

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journal = "Molecular Cell",

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T1 - Targeting HSP70 for Cancer Therapy

AU - Galluzzi, Lorenzo

AU - Giordanetto, Fabrizio

AU - Kroemer, Guido

PY - 2009/10/23

Y1 - 2009/10/23

N2 - In a recent issue of Molecular Cell, Leu et al. (2009) demonstrate that a chemical inhibitor of HSP70 exerts prominent tumor-selective cytotoxic effects, thereby lending further support to the notion that non-oncogene addiction constitutes a promising target for anticancer therapy.

AB - In a recent issue of Molecular Cell, Leu et al. (2009) demonstrate that a chemical inhibitor of HSP70 exerts prominent tumor-selective cytotoxic effects, thereby lending further support to the notion that non-oncogene addiction constitutes a promising target for anticancer therapy.

KW - Animals

KW - Drug Resistance, Neoplasm/drug effects

KW - HSP70 Heat-Shock Proteins/metabolism

KW - HSP90 Heat-Shock Proteins/metabolism

KW - Humans

KW - Models, Molecular

KW - Neoplasms/therapy

KW - Sulfonamides/pharmacology

UR - https://www.scopus.com/pages/publications/70350120030

U2 - 10.1016/j.molcel.2009.10.003

DO - 10.1016/j.molcel.2009.10.003

M3 - Short survey

C2 - 19854128

AN - SCOPUS:70350120030

SN - 1097-2765

VL - 36

SP - 176

EP - 177

JO - Molecular Cell

JF - Molecular Cell

IS - 2

ER -

Targeting HSP70 for Cancer Therapy

Abstract

UN SDGs

Keywords

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