T cell-independent abscopal responses to radiotherapy

Emma Guilbaud; Takahiro Yamazaki; Lorenzo Galluzzi

doi:10.1016/j.trecan.2022.12.005

T cell-independent abscopal responses to radiotherapy

Emma Guilbaud, Takahiro Yamazaki, Lorenzo Galluzzi

Cornell University

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

When used according to specific dose/fractionation schedules, focal radiotherapy can elicit a systemic anticancer immune response that limits the growth of distant, non-irradiated tumors. Recent data suggest that, at least in some settings, intratumoral macrophages can be educated by CD47 blockage to promote such an ‘abscopal’ response independent of CD8⁺ T cells.

Original language	English
Pages (from-to)	93-95
Number of pages	3
Journal	Trends in Cancer
Volume	9
Issue number	2
DOIs	https://doi.org/10.1016/j.trecan.2022.12.005
State	Published - Feb 2023
Externally published	Yes

Keywords

CD8-Positive T-Lymphocytes
Dose Fractionation, Radiation
Humans
Neoplasms/pathology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.trecan.2022.12.005

Cite this

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title = "T cell-independent abscopal responses to radiotherapy",

abstract = "When used according to specific dose/fractionation schedules, focal radiotherapy can elicit a systemic anticancer immune response that limits the growth of distant, non-irradiated tumors. Recent data suggest that, at least in some settings, intratumoral macrophages can be educated by CD47 blockage to promote such an {\textquoteleft}abscopal{\textquoteright} response independent of CD8+ T cells.",

keywords = "CD8-Positive T-Lymphocytes, Dose Fractionation, Radiation, Humans, Neoplasms/pathology",

author = "Emma Guilbaud and Takahiro Yamazaki and Lorenzo Galluzzi",

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AU - Guilbaud, Emma

AU - Yamazaki, Takahiro

AU - Galluzzi, Lorenzo

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AB - When used according to specific dose/fractionation schedules, focal radiotherapy can elicit a systemic anticancer immune response that limits the growth of distant, non-irradiated tumors. Recent data suggest that, at least in some settings, intratumoral macrophages can be educated by CD47 blockage to promote such an ‘abscopal’ response independent of CD8+ T cells.

KW - CD8-Positive T-Lymphocytes

KW - Dose Fractionation, Radiation

KW - Humans

KW - Neoplasms/pathology

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M3 - Article

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ER -

T cell-independent abscopal responses to radiotherapy

Abstract

Keywords

UN SDGs

Access to Document

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