Subasumstat, a first-in-class inhibitor of SUMO-activating enzyme, demonstrates dose-dependent target engagement and SUMOylation inhibition, leading to rapid activation of innate and adaptive immune responses in the dose escalation portion of a phase 1/2 clinical study

G. Saggu; D. Stroopinsky; A. Z. Dudek; A. J. Olszanski; D. Juric; A. Dowlati; U. Vaishampayan; H. Assad; J. Rodón; J. Gibbs; J. Green; Z. Du; R. Rudicell; K. Kannan; R. Gharavi; A. Gomez-Pinillos; R. J. Fram; A. Berger; K. Sachsenmeier; S. Kasar

doi:10.1016/S0959-8049(22)01134-0

Subasumstat, a first-in-class inhibitor of SUMO-activating enzyme, demonstrates dose-dependent target engagement and SUMOylation inhibition, leading to rapid activation of innate and adaptive immune responses in the dose escalation portion of a phase 1/2 clinical study

G. Saggu
, D. Stroopinsky
, A. Z. Dudek
, A. J. Olszanski
, D. Juric
, A. Dowlati
, U. Vaishampayan
, H. Assad
, J. Rodón
, J. Gibbs
, J. Green
, Z. Du
, R. Rudicell
, K. Kannan
, R. Gharavi
, A. Gomez-Pinillos
, R. J. Fram
, A. Berger
, K. Sachsenmeier
, S. Kasar

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Original language	English
Pages (from-to)	S125-S126
Journal	European Journal of Cancer
Volume	174
DOIs	https://doi.org/10.1016/S0959-8049(22)01134-0
State	Published - Oct 2022

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Saggu, G., Stroopinsky, D., Dudek, A. Z., Olszanski, A. J., Juric, D., Dowlati, A., Vaishampayan, U., Assad, H., Rodón, J., Gibbs, J., Green, J., Du, Z., Rudicell, R., Kannan, K., Gharavi, R., Gomez-Pinillos, A., Fram, R. J., Berger, A., Sachsenmeier, K., & Kasar, S. (2022). Subasumstat, a first-in-class inhibitor of SUMO-activating enzyme, demonstrates dose-dependent target engagement and SUMOylation inhibition, leading to rapid activation of innate and adaptive immune responses in the dose escalation portion of a phase 1/2 clinical study. European Journal of Cancer, 174, S125-S126. https://doi.org/10.1016/S0959-8049(22)01134-0

Saggu, G. ; Stroopinsky, D. ; Dudek, A. Z. et al. / Subasumstat, a first-in-class inhibitor of SUMO-activating enzyme, demonstrates dose-dependent target engagement and SUMOylation inhibition, leading to rapid activation of innate and adaptive immune responses in the dose escalation portion of a phase 1/2 clinical study. In: European Journal of Cancer. 2022 ; Vol. 174. pp. S125-S126.

@article{befdf6b77f294249878fb3195a4391cc,

title = "Subasumstat, a first-in-class inhibitor of SUMO-activating enzyme, demonstrates dose-dependent target engagement and SUMOylation inhibition, leading to rapid activation of innate and adaptive immune responses in the dose escalation portion of a phase 1/2 clinical study",

author = "G. Saggu and D. Stroopinsky and Dudek, \{A. Z.\} and Olszanski, \{A. J.\} and D. Juric and A. Dowlati and U. Vaishampayan and H. Assad and J. Rod{\'o}n and J. Gibbs and J. Green and Z. Du and R. Rudicell and K. Kannan and R. Gharavi and A. Gomez-Pinillos and Fram, \{R. J.\} and A. Berger and K. Sachsenmeier and S. Kasar",

year = "2022",

month = oct,

doi = "10.1016/S0959-8049(22)01134-0",

language = "English",

volume = "174",

pages = "S125--S126",

journal = "European Journal of Cancer",

issn = "0959-8049",

publisher = "Elsevier Ltd.",

}

Saggu, G, Stroopinsky, D, Dudek, AZ, Olszanski, AJ, Juric, D, Dowlati, A, Vaishampayan, U, Assad, H, Rodón, J, Gibbs, J, Green, J, Du, Z, Rudicell, R, Kannan, K, Gharavi, R, Gomez-Pinillos, A, Fram, RJ, Berger, A, Sachsenmeier, K & Kasar, S 2022, 'Subasumstat, a first-in-class inhibitor of SUMO-activating enzyme, demonstrates dose-dependent target engagement and SUMOylation inhibition, leading to rapid activation of innate and adaptive immune responses in the dose escalation portion of a phase 1/2 clinical study', European Journal of Cancer, vol. 174, pp. S125-S126. https://doi.org/10.1016/S0959-8049(22)01134-0

Subasumstat, a first-in-class inhibitor of SUMO-activating enzyme, demonstrates dose-dependent target engagement and SUMOylation inhibition, leading to rapid activation of innate and adaptive immune responses in the dose escalation portion of a phase 1/2 clinical study. / Saggu, G.; Stroopinsky, D.; Dudek, A. Z. et al.
In: European Journal of Cancer, Vol. 174, 10.2022, p. S125-S126.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Subasumstat, a first-in-class inhibitor of SUMO-activating enzyme, demonstrates dose-dependent target engagement and SUMOylation inhibition, leading to rapid activation of innate and adaptive immune responses in the dose escalation portion of a phase 1/2 clinical study

AU - Saggu, G.

AU - Stroopinsky, D.

AU - Dudek, A. Z.

AU - Olszanski, A. J.

AU - Juric, D.

AU - Dowlati, A.

AU - Vaishampayan, U.

AU - Assad, H.

AU - Rodón, J.

AU - Gibbs, J.

AU - Green, J.

AU - Du, Z.

AU - Rudicell, R.

AU - Kannan, K.

AU - Gharavi, R.

AU - Gomez-Pinillos, A.

AU - Fram, R. J.

AU - Berger, A.

AU - Sachsenmeier, K.

AU - Kasar, S.

PY - 2022/10

Y1 - 2022/10

UR - https://www.scopus.com/pages/publications/85140445601

U2 - 10.1016/S0959-8049(22)01134-0

DO - 10.1016/S0959-8049(22)01134-0

M3 - Article

AN - SCOPUS:85140445601

SN - 0959-8049

VL - 174

SP - S125-S126

JO - European Journal of Cancer

JF - European Journal of Cancer

ER -

Saggu G, Stroopinsky D, Dudek AZ, Olszanski AJ, Juric D, Dowlati A et al. Subasumstat, a first-in-class inhibitor of SUMO-activating enzyme, demonstrates dose-dependent target engagement and SUMOylation inhibition, leading to rapid activation of innate and adaptive immune responses in the dose escalation portion of a phase 1/2 clinical study. European Journal of Cancer. 2022 Oct;174:S125-S126. doi: 10.1016/S0959-8049(22)01134-0

Subasumstat, a first-in-class inhibitor of SUMO-activating enzyme, demonstrates dose-dependent target engagement and SUMOylation inhibition, leading to rapid activation of innate and adaptive immune responses in the dose escalation portion of a phase 1/2 clinical study

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