Structure and function of histone chaperone FACT

M. T. Bondarenko, N. V. Maluchenko, M. E. Valieva, N. S. Gerasimova, O. I. Kulaeva, P. G. Georgiev, V. M. Studitsky

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

FACT is heterodimer protein complex and histone chaperone that plays an important role in maintaining and modifying chromatin structure during various DNA-dependent processes. FACT is involved in nucleosome assembly de novo and in the preservation and recovery of the nucleosome structure during and after transcription, replication and repair of DNA. During transcript elongation FACT reduces the height of the nucleosome barrier and supports survival of the nucleosomes during and after passage of RNA polymerase II. In this process FACT interacts with histone H2A-H2B dimer in nucleosomes, thus facilitating uncoiling of nucleosomal DNA from the octamer of histones; it also facilitates subsequent recovery of the canonical structure of the nucleosome after transcription. FACT also plays an important role in transformation of human cells and in maintaining the viability of the tumor cells.

Original languageEnglish
Pages (from-to)891-904
Number of pages14
JournalMolekulyarnaya Biologiya
Volume49
Issue number6
DOIs
StatePublished - Nov 1 2015
Externally publishedYes

Keywords

  • FACT
  • chromatin
  • histones H2A-H2B
  • transcription

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