Structure and function of histone chaperone FACT

M. T. Bondarenko, N. V. Maluchenko, M. E. Valieva, N. S. Gerasimova, O. I. Kulaeva, P. G. Georgiev, V. M. Studitsky

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

FACT is heterodimer protein complex and histone chaperone that plays an important role in maintaining and modifying the chromatin structure during various DNA-dependent processes. FACT is involved in nucleosome assembly de novo and in the preservation and recovery of the nucleosome structure during and after transcription, replication and DNA repair. During transcript elongation, FACT reduces the height of the nucleosome barrier and supports the maintenance of nucleosomes during and after the passage of RNA polymerase II. In this process, FACT interacts with histone H2A–H2B dimer within nucleosomes, thus, facilitating uncoiling of nucleosomal DNA from the octamer of histones. It also facilitates the subsequent recovery of the canonical nucleosome structure after transcription. FACT also plays an important role in the transformation of human cells and in maintaining the viability of tumor cells.

Original languageEnglish
Pages (from-to)796-809
Number of pages14
JournalMolecular Biology
Volume49
Issue number6
DOIs
StatePublished - Nov 2015

Keywords

  • chromatin
  • FACT
  • histones H2A–H2B
  • transcription

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