STIMATE reveals a STIM1 transitional state

Robert Hooper; Jonathan Soboloff

doi:10.1038/ncb3245

STIMATE reveals a STIM1 transitional state

Robert Hooper, Jonathan Soboloff

Temple University

Research output: Contribution to journal › Short survey › peer-review

19 Scopus citations

Abstract

Decreases in endoplasmic reticulum calcium content are sensed by resident STIM proteins, which can activate plasma membrane Orai channels to facilitate Ca(2+) entry. The role of STIMATE, a previously unknown component of the store-operated calcium entry complex, has now been identified and defined.

Original language	English
Pages (from-to)	1232-1234
Number of pages	3
Journal	Nature Cell Biology
Volume	17
Issue number	10
DOIs	https://doi.org/10.1038/ncb3245
State	Published - Oct 3 2015

Keywords

Animals
Calcium/metabolism
Cell Membrane/metabolism
Endoplasmic Reticulum/metabolism
Humans
Membrane Proteins/metabolism
Proteome/metabolism

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10.1038/ncb3245

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abstract = "Decreases in endoplasmic reticulum calcium content are sensed by resident STIM proteins, which can activate plasma membrane Orai channels to facilitate Ca(2+) entry. The role of STIMATE, a previously unknown component of the store-operated calcium entry complex, has now been identified and defined.",

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author = "Robert Hooper and Jonathan Soboloff",

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KW - Calcium/metabolism

KW - Cell Membrane/metabolism

KW - Endoplasmic Reticulum/metabolism

KW - Humans

KW - Membrane Proteins/metabolism

KW - Proteome/metabolism

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STIMATE reveals a STIM1 transitional state

Abstract

Keywords

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