STIM proteins: Dynamic calcium signal transducers

Jonathan Soboloff; Brad S. Rothberg; Muniswamy Madesh; Donald L. Gill

doi:10.1038/nrm3414

STIM proteins: Dynamic calcium signal transducers

Jonathan Soboloff, Brad S. Rothberg, Muniswamy Madesh, Donald L. Gill

Temple University

Research output: Contribution to journal › Review article › peer-review

567 Scopus citations

Abstract

Stromal interaction molecule (STIM) proteins function in cells as dynamic coordinators of cellular calcium (Ca²⁺) signals. Spanning the endoplasmic reticulum (ER) membrane, they sense tiny changes in the levels of Ca²⁺ stored within the ER lumen. As ER Ca²⁺ is released to generate primary Ca²⁺ signals, STIM proteins undergo an intricate activation reaction and rapidly translocate into junctions formed between the ER and the plasma membrane. There, STIM proteins tether and activate the highly Ca²⁺-selective Orai channels to mediate finely controlled Ca ²⁺ signals and to homeostatically balance cellular Ca²⁺. Details are emerging on the remarkable organization within these STIM-induced junctional microdomains and the identification of new regulators and alternative target proteins for STIM.

Original language	English
Pages (from-to)	549-565
Number of pages	17
Journal	Nature Reviews Molecular Cell Biology
Volume	13
Issue number	9
DOIs	https://doi.org/10.1038/nrm3414
State	Published - Sep 2012
Externally published	Yes

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title = "STIM proteins: Dynamic calcium signal transducers",

abstract = "Stromal interaction molecule (STIM) proteins function in cells as dynamic coordinators of cellular calcium (Ca2+) signals. Spanning the endoplasmic reticulum (ER) membrane, they sense tiny changes in the levels of Ca2+ stored within the ER lumen. As ER Ca2+ is released to generate primary Ca2+ signals, STIM proteins undergo an intricate activation reaction and rapidly translocate into junctions formed between the ER and the plasma membrane. There, STIM proteins tether and activate the highly Ca2+-selective Orai channels to mediate finely controlled Ca 2+ signals and to homeostatically balance cellular Ca2+. Details are emerging on the remarkable organization within these STIM-induced junctional microdomains and the identification of new regulators and alternative target proteins for STIM.",

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AU - Rothberg, Brad S.

AU - Madesh, Muniswamy

AU - Gill, Donald L.

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AB - Stromal interaction molecule (STIM) proteins function in cells as dynamic coordinators of cellular calcium (Ca2+) signals. Spanning the endoplasmic reticulum (ER) membrane, they sense tiny changes in the levels of Ca2+ stored within the ER lumen. As ER Ca2+ is released to generate primary Ca2+ signals, STIM proteins undergo an intricate activation reaction and rapidly translocate into junctions formed between the ER and the plasma membrane. There, STIM proteins tether and activate the highly Ca2+-selective Orai channels to mediate finely controlled Ca 2+ signals and to homeostatically balance cellular Ca2+. Details are emerging on the remarkable organization within these STIM-induced junctional microdomains and the identification of new regulators and alternative target proteins for STIM.

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JO - Nature Reviews Molecular Cell Biology

JF - Nature Reviews Molecular Cell Biology

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ER -

STIM proteins: Dynamic calcium signal transducers

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