Spontaneous and therapeutic abortions and the risk of breast cancer among BRCA mutation carriers

Eitan Friedman; Joanne Kotsopoulos; Jan Lubinski; Henry T. Lynch; Parviz Ghadirian; Susan L. Neuhausen; Claudine Isaacs; Barbara Weber; William D. Foulkes; Pal Moller; Barry Rosen; Charmaine Kim-Sing; Ruth Gershoni-Baruch; Peter Ainsworth; Mary Daly; Nadine Tung; Andrea Eisen; Olufunmilayo I. Olopade; Beth Karlan; Howard M. Saal; Judy E. Garber; Gad Rennert; Dawna Gilchrist; Charis Eng; Kenneth Offit; Michael Osborne; Ping Sun; Steven A. Narod; Jane McLennan; David Fishman; Sofia Merajver; Wendy McKinnon; Marie Wood; Albert Chudley; Ellen Warner; Jeffrey Weitzel; Gareth Evans; Edmond Lemire; Hakkan Olsson; Wendy Meschino; Diane Provencher; Gordon Mills; Boris Pasche; Taya Fallen; Barbara Pasini; Cristina Bellati; Fergus Couch; Teresa Wagner; Linda Kipper; Patricia Steele

doi:10.1186/bcr1387

Spontaneous and therapeutic abortions and the risk of breast cancer among BRCA mutation carriers

Eitan Friedman
, Joanne Kotsopoulos
, Jan Lubinski
, Henry T. Lynch
, Parviz Ghadirian
, Susan L. Neuhausen
, Claudine Isaacs
, Barbara Weber
, William D. Foulkes
, Pal Moller
, Barry Rosen
, Charmaine Kim-Sing
, Ruth Gershoni-Baruch
, Peter Ainsworth
, Mary Daly
, Nadine Tung
, Andrea Eisen
, Olufunmilayo I. Olopade
, Beth Karlan
, Howard M. Saal

Judy E. Garber, Gad Rennert, Dawna Gilchrist, Charis Eng, Kenneth Offit, Michael Osborne, Ping Sun, Steven A. Narod, Jane McLennan, David Fishman, Sofia Merajver, Wendy McKinnon, Marie Wood, Albert Chudley, Ellen Warner, Jeffrey Weitzel, Gareth Evans, Edmond Lemire, Hakkan Olsson, Wendy Meschino, Diane Provencher, Gordon Mills, Boris Pasche, Taya Fallen, Barbara Pasini, Cristina Bellati, Fergus Couch, Teresa Wagner, Linda Kipper, Patricia Steele

Sheba Medical Center at Tel Hashomer
Tel Aviv University
University of Toronto
Pomeranian Medical University in Szczecin
Creighton University
Centre Hospitalier de l’Université de Montréal Research Center
University of California at Irvine
Georgetown University
University of Pennsylvania
McGill University
University of Oslo
Princess Margaret Cancer Centre
British Columbia Cancer Agency
Rambam Health Care Campus
Western University
Beth Israel Deaconess Medical Center
University of Chicago
Cedars-Sinai Medical Center
Cincinnati Children's Hospital Medical Center
Dana-Farber Cancer Institute
Clalit Health Services
University of Alberta
Ohio State University
Memorial Sloan-Kettering Cancer Center
Strang Cancer Prevention Center

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

Introduction: BRCA1 and BRCA2 mutation carriers are at increased risk for developing both breast and ovarian cancer. It has been suggested that carriers of BRCA1/2 mutations may also be at increased risk of having recurrent (three or more) miscarriages. Several reproductive factors have been shown to influence the risk of breast cancer in mutation carriers, but the effects of spontaneous and therapeutic abortions on the risk of hereditary breast cancer risk have not been well studied to date. Methods: In a matched case-control study, the frequencies of spontaneous abortions were compared among 1,878 BRCA1 mutation carriers, 950 BRCA2 mutation carriers and 657 related non-carrier controls. The rates of spontaneous and therapeutic abortions were compared for carriers with and without breast cancer. Results: There was no difference in the rate of spontaneous abortions between carriers of BRCA1 or BRCA2 mutations and non-carriers. The number of spontaneous abortions was not associated with breast cancer risk among BRCA1 or BRCA2 mutation carriers. However, BRCA2 carriers who had two or more therapeutic abortions faced a 64% decrease in the risk of breast cancer (odds ratio = 0.36; 95% confidence interval 0.16-0.83; p = 0.02). Conclusion: Carrying a BRCA1 or BRCA2 mutation is not a risk factor for spontaneous abortions and spontaneous abortions do not appear to influence the risk of breast cancer in carriers of BRCA1 or BRCA2 mutations. However, having two or more therapeutic abortions may be associated with a lowered risk of breast cancer among BRCA2 carriers.

Original language	English
Article number	R15
Journal	Breast Cancer Research
Volume	8
Issue number	2
DOIs	https://doi.org/10.1186/bcr1387
State	Published - Mar 21 2006

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Friedman, E., Kotsopoulos, J., Lubinski, J., Lynch, H. T., Ghadirian, P., Neuhausen, S. L., Isaacs, C., Weber, B., Foulkes, W. D., Moller, P., Rosen, B., Kim-Sing, C., Gershoni-Baruch, R., Ainsworth, P., Daly, M., Tung, N., Eisen, A., Olopade, O. I., Karlan, B., ... Steele, P. (2006). Spontaneous and therapeutic abortions and the risk of breast cancer among BRCA mutation carriers. Breast Cancer Research, 8(2), Article R15. https://doi.org/10.1186/bcr1387

@article{6b212dae065f4d97b0497f930a79c23a,

title = "Spontaneous and therapeutic abortions and the risk of breast cancer among BRCA mutation carriers",

abstract = "Introduction: BRCA1 and BRCA2 mutation carriers are at increased risk for developing both breast and ovarian cancer. It has been suggested that carriers of BRCA1/2 mutations may also be at increased risk of having recurrent (three or more) miscarriages. Several reproductive factors have been shown to influence the risk of breast cancer in mutation carriers, but the effects of spontaneous and therapeutic abortions on the risk of hereditary breast cancer risk have not been well studied to date. Methods: In a matched case-control study, the frequencies of spontaneous abortions were compared among 1,878 BRCA1 mutation carriers, 950 BRCA2 mutation carriers and 657 related non-carrier controls. The rates of spontaneous and therapeutic abortions were compared for carriers with and without breast cancer. Results: There was no difference in the rate of spontaneous abortions between carriers of BRCA1 or BRCA2 mutations and non-carriers. The number of spontaneous abortions was not associated with breast cancer risk among BRCA1 or BRCA2 mutation carriers. However, BRCA2 carriers who had two or more therapeutic abortions faced a 64\% decrease in the risk of breast cancer (odds ratio = 0.36; 95\% confidence interval 0.16-0.83; p = 0.02). Conclusion: Carrying a BRCA1 or BRCA2 mutation is not a risk factor for spontaneous abortions and spontaneous abortions do not appear to influence the risk of breast cancer in carriers of BRCA1 or BRCA2 mutations. However, having two or more therapeutic abortions may be associated with a lowered risk of breast cancer among BRCA2 carriers.",

author = "Eitan Friedman and Joanne Kotsopoulos and Jan Lubinski and Lynch, \{Henry T.\} and Parviz Ghadirian and Neuhausen, \{Susan L.\} and Claudine Isaacs and Barbara Weber and Foulkes, \{William D.\} and Pal Moller and Barry Rosen and Charmaine Kim-Sing and Ruth Gershoni-Baruch and Peter Ainsworth and Mary Daly and Nadine Tung and Andrea Eisen and Olopade, \{Olufunmilayo I.\} and Beth Karlan and Saal, \{Howard M.\} and Garber, \{Judy E.\} and Gad Rennert and Dawna Gilchrist and Charis Eng and Kenneth Offit and Michael Osborne and Ping Sun and Narod, \{Steven A.\} and Jane McLennan and David Fishman and Sofia Merajver and Wendy McKinnon and Marie Wood and Albert Chudley and Ellen Warner and Jeffrey Weitzel and Gareth Evans and Edmond Lemire and Hakkan Olsson and Wendy Meschino and Diane Provencher and Gordon Mills and Boris Pasche and Taya Fallen and Barbara Pasini and Cristina Bellati and Fergus Couch and Teresa Wagner and Linda Kipper and Patricia Steele",

year = "2006",

month = mar,

day = "21",

doi = "10.1186/bcr1387",

language = "English",

volume = "8",

journal = "Breast Cancer Research",

issn = "1465-542X",

publisher = "BioMed Central Ltd.",

number = "2",

}

Friedman, E, Kotsopoulos, J, Lubinski, J, Lynch, HT, Ghadirian, P, Neuhausen, SL, Isaacs, C, Weber, B, Foulkes, WD, Moller, P, Rosen, B, Kim-Sing, C, Gershoni-Baruch, R, Ainsworth, P, Daly, M, Tung, N, Eisen, A, Olopade, OI, Karlan, B, Saal, HM, Garber, JE, Rennert, G, Gilchrist, D, Eng, C, Offit, K, Osborne, M, Sun, P, Narod, SA, McLennan, J, Fishman, D, Merajver, S, McKinnon, W, Wood, M, Chudley, A, Warner, E, Weitzel, J, Evans, G, Lemire, E, Olsson, H, Meschino, W, Provencher, D, Mills, G, Pasche, B, Fallen, T, Pasini, B, Bellati, C, Couch, F, Wagner, T, Kipper, L & Steele, P 2006, 'Spontaneous and therapeutic abortions and the risk of breast cancer among BRCA mutation carriers', Breast Cancer Research, vol. 8, no. 2, R15. https://doi.org/10.1186/bcr1387

TY - JOUR

T1 - Spontaneous and therapeutic abortions and the risk of breast cancer among BRCA mutation carriers

AU - Friedman, Eitan

AU - Kotsopoulos, Joanne

AU - Lubinski, Jan

AU - Lynch, Henry T.

AU - Ghadirian, Parviz

AU - Neuhausen, Susan L.

AU - Isaacs, Claudine

AU - Weber, Barbara

AU - Foulkes, William D.

AU - Moller, Pal

AU - Rosen, Barry

AU - Kim-Sing, Charmaine

AU - Gershoni-Baruch, Ruth

AU - Ainsworth, Peter

AU - Daly, Mary

AU - Tung, Nadine

AU - Eisen, Andrea

AU - Olopade, Olufunmilayo I.

AU - Karlan, Beth

AU - Saal, Howard M.

AU - Garber, Judy E.

AU - Rennert, Gad

AU - Gilchrist, Dawna

AU - Eng, Charis

AU - Offit, Kenneth

AU - Osborne, Michael

AU - Sun, Ping

AU - Narod, Steven A.

AU - McLennan, Jane

AU - Fishman, David

AU - Merajver, Sofia

AU - McKinnon, Wendy

AU - Wood, Marie

AU - Chudley, Albert

AU - Warner, Ellen

AU - Weitzel, Jeffrey

AU - Evans, Gareth

AU - Lemire, Edmond

AU - Olsson, Hakkan

AU - Meschino, Wendy

AU - Provencher, Diane

AU - Mills, Gordon

AU - Pasche, Boris

AU - Fallen, Taya

AU - Pasini, Barbara

AU - Bellati, Cristina

AU - Couch, Fergus

AU - Wagner, Teresa

AU - Kipper, Linda

AU - Steele, Patricia

PY - 2006/3/21

Y1 - 2006/3/21

N2 - Introduction: BRCA1 and BRCA2 mutation carriers are at increased risk for developing both breast and ovarian cancer. It has been suggested that carriers of BRCA1/2 mutations may also be at increased risk of having recurrent (three or more) miscarriages. Several reproductive factors have been shown to influence the risk of breast cancer in mutation carriers, but the effects of spontaneous and therapeutic abortions on the risk of hereditary breast cancer risk have not been well studied to date. Methods: In a matched case-control study, the frequencies of spontaneous abortions were compared among 1,878 BRCA1 mutation carriers, 950 BRCA2 mutation carriers and 657 related non-carrier controls. The rates of spontaneous and therapeutic abortions were compared for carriers with and without breast cancer. Results: There was no difference in the rate of spontaneous abortions between carriers of BRCA1 or BRCA2 mutations and non-carriers. The number of spontaneous abortions was not associated with breast cancer risk among BRCA1 or BRCA2 mutation carriers. However, BRCA2 carriers who had two or more therapeutic abortions faced a 64% decrease in the risk of breast cancer (odds ratio = 0.36; 95% confidence interval 0.16-0.83; p = 0.02). Conclusion: Carrying a BRCA1 or BRCA2 mutation is not a risk factor for spontaneous abortions and spontaneous abortions do not appear to influence the risk of breast cancer in carriers of BRCA1 or BRCA2 mutations. However, having two or more therapeutic abortions may be associated with a lowered risk of breast cancer among BRCA2 carriers.

AB - Introduction: BRCA1 and BRCA2 mutation carriers are at increased risk for developing both breast and ovarian cancer. It has been suggested that carriers of BRCA1/2 mutations may also be at increased risk of having recurrent (three or more) miscarriages. Several reproductive factors have been shown to influence the risk of breast cancer in mutation carriers, but the effects of spontaneous and therapeutic abortions on the risk of hereditary breast cancer risk have not been well studied to date. Methods: In a matched case-control study, the frequencies of spontaneous abortions were compared among 1,878 BRCA1 mutation carriers, 950 BRCA2 mutation carriers and 657 related non-carrier controls. The rates of spontaneous and therapeutic abortions were compared for carriers with and without breast cancer. Results: There was no difference in the rate of spontaneous abortions between carriers of BRCA1 or BRCA2 mutations and non-carriers. The number of spontaneous abortions was not associated with breast cancer risk among BRCA1 or BRCA2 mutation carriers. However, BRCA2 carriers who had two or more therapeutic abortions faced a 64% decrease in the risk of breast cancer (odds ratio = 0.36; 95% confidence interval 0.16-0.83; p = 0.02). Conclusion: Carrying a BRCA1 or BRCA2 mutation is not a risk factor for spontaneous abortions and spontaneous abortions do not appear to influence the risk of breast cancer in carriers of BRCA1 or BRCA2 mutations. However, having two or more therapeutic abortions may be associated with a lowered risk of breast cancer among BRCA2 carriers.

UR - https://www.scopus.com/pages/publications/33746476567

U2 - 10.1186/bcr1387

DO - 10.1186/bcr1387

M3 - Article

C2 - 16563180

AN - SCOPUS:33746476567

SN - 1465-542X

VL - 8

JO - Breast Cancer Research

JF - Breast Cancer Research

IS - 2

M1 - R15

ER -

Spontaneous and therapeutic abortions and the risk of breast cancer among BRCA mutation carriers

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