Abstract
This chapter provides answers to practice-based questions with case studies covering the new principles of diagnosis, classification, staging, treatment, and outcomes in the rapidly advancing field of soft tissue sarcomas (STS). STS constitute a group of mesenchymal cell tumors that can be classified based on the site of origin, such as extremity or retroperitoneal. They are rare cancers that represent <1% of all solid tumors, but unlike other solid tumors, these malignancies are seen commonly in the pediatric population. Pathologic evaluation requires immunohistochemistry and molecular testing. Surgery remains the gold standard for primary STS management when feasible, with consideration of radiation and/or systemic therapy based on location and histology. Clinicians team emphasizes the importance of upfront biopsy of tumors to determine the optimum multidisciplinary approach of initial therapy to improve outcomes, decrease the chance of local and distant recurrence, and maximize quality of life.
Original language | English |
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Title of host publication | Cancer Consult |
Subtitle of host publication | Expertise in Clinical Practice, Volume 1: Solid Tumors and Supportive Care |
Publisher | wiley |
Pages | 579-593 |
Number of pages | 15 |
Volume | 1 |
ISBN (Electronic) | 9781119823766 |
ISBN (Print) | 9781119823735 |
DOIs | |
State | Published - Jan 1 2023 |
Keywords
- Immunohistochemistry
- Mesenchymal cell tumors
- Molecular testing
- Pathologic evaluation
- Quality of life
- Soft tissue sarcomas