Soft Tissue Sarcomas

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

This chapter provides answers to practice-based questions with case studies covering the new principles of diagnosis, classification, staging, treatment, and outcomes in the rapidly advancing field of soft tissue sarcomas (STS). STS constitute a group of mesenchymal cell tumors that can be classified based on the site of origin, such as extremity or retroperitoneal. They are rare cancers that represent <1% of all solid tumors, but unlike other solid tumors, these malignancies are seen commonly in the pediatric population. Pathologic evaluation requires immunohistochemistry and molecular testing. Surgery remains the gold standard for primary STS management when feasible, with consideration of radiation and/or systemic therapy based on location and histology. Clinicians team emphasizes the importance of upfront biopsy of tumors to determine the optimum multidisciplinary approach of initial therapy to improve outcomes, decrease the chance of local and distant recurrence, and maximize quality of life.

Original languageEnglish
Title of host publicationCancer Consult
Subtitle of host publicationExpertise in Clinical Practice, Volume 1: Solid Tumors and Supportive Care
Publisherwiley
Pages579-593
Number of pages15
Volume1
ISBN (Electronic)9781119823766
ISBN (Print)9781119823735
DOIs
StatePublished - Jan 1 2023

Keywords

  • Immunohistochemistry
  • Mesenchymal cell tumors
  • Molecular testing
  • Pathologic evaluation
  • Quality of life
  • Soft tissue sarcomas

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