Abstract
An unusual case of small lymphocytic non-Hodgkin's lymphoma of suppressor/cytotoxic T-cell phenotype is described. The patient presented with significant involvement of the spleen, lymph nodes, and bone marrow, but without a leukemic phase. Most small lymphocytic lymphomas are of B-cell phenotype, and those of T-cell origin are overwhelmingly of T-helper/inducer phenotype. Furthermore, T-cell lymphoproliferative lesions of suppressor/cytotoxic phenotype generally present as leukemias comprising large granular lymphocytes. This case reveals that suppressor/cytotoxic T lymphocytes may give rise to a lymphoproliferative disorder with a distinctive phenotype and presentation.
Original language | English |
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Pages (from-to) | 1253-1256 |
Number of pages | 4 |
Journal | Human pathology |
Volume | 24 |
Issue number | 11 |
DOIs | |
State | Published - Nov 1993 |
Keywords
- CD4 Antigens/analysis
- CD4-CD8 Ratio
- CD8 Antigens/analysis
- Female
- Genotype
- Humans
- Immunohistochemistry
- Leukemia, Lymphocytic, Chronic, B-Cell/immunology
- Middle Aged
- Phenotype
- T-Lymphocytes, Cytotoxic/immunology
- T-Lymphocytes, Regulatory/immunology