Small lymphocytic non-Hodgkin's lymphoma of suppressor/cytotoxic T-cell phenotype [CD4(-), CD8(+)]

David M. Dorfman, Janina A. Longtine, David S. Weinberg, Geraldine S. Pinkus

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

An unusual case of small lymphocytic non-Hodgkin's lymphoma of suppressor/cytotoxic T-cell phenotype is described. The patient presented with significant involvement of the spleen, lymph nodes, and bone marrow, but without a leukemic phase. Most small lymphocytic lymphomas are of B-cell phenotype, and those of T-cell origin are overwhelmingly of T-helper/inducer phenotype. Furthermore, T-cell lymphoproliferative lesions of suppressor/cytotoxic phenotype generally present as leukemias comprising large granular lymphocytes. This case reveals that suppressor/cytotoxic T lymphocytes may give rise to a lymphoproliferative disorder with a distinctive phenotype and presentation.

Original languageEnglish
Pages (from-to)1253-1256
Number of pages4
JournalHuman pathology
Volume24
Issue number11
DOIs
StatePublished - Nov 1993

Keywords

  • CD4 Antigens/analysis
  • CD4-CD8 Ratio
  • CD8 Antigens/analysis
  • Female
  • Genotype
  • Humans
  • Immunohistochemistry
  • Leukemia, Lymphocytic, Chronic, B-Cell/immunology
  • Middle Aged
  • Phenotype
  • T-Lymphocytes, Cytotoxic/immunology
  • T-Lymphocytes, Regulatory/immunology

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